缺血预处置对大鼠脑缺血再灌流线粒体膜流动性及ATP含量的影响  

The effect of ischemia precondition on the mitochordia membrane fluidity and ATP content in rat cerebral ischemia reperfusion

作　　者：贾栋[1] 高国栋[1] 

机构地区：[1]西安第四军医大学唐都医院神经外科

出　　处：《卒中与神经疾病》1999年第2期65-67,共3页Stroke and Nervous Diseases

摘　　要：目的方法：在大鼠脑缺血再灌流损伤模型上观察，缺血预处置对大鼠脑组织线粒体膜流动性及ＡＴＰ含量的影响。结果：发现ＩＰＣ可以使脑ＩＲ组织线粒体膜流动性及ＡＴＰ含量下降程度减少（与对照组比较）。结论：ＩＰＣ对大鼠脑ＩＲ组织有保护作用。其保护机理可能与ＦＩＦＯＡＴＰ酶、蛋白激酶（ＰＫＣ）及氧自由基清除系统有关。Abstract Objective and methodsBZ:On the model of cerebral ischemiareperfusion (IR),the effect of ischemia precondition (IPC) on mitochordia membrane fluidity and ATP content was observed. Results :IPC could decrease the falling degree of mitochordia membrane fluidity and ATP content in cerebral ischemiareperfusion tissue (compared with shamoperated groups). Conclusion :IPC had protective function to cerebral ischemia reperfusing tissue,in which the function perhaps correlated with FIFOATP dinase,protein kinase C and the clearance system of oxyradical. cerebral ischemia reperfusionratATPmitochordia membrane fluidityischemia precondition

关 键 词：脑缺血 再灌注损伤 线粒体膜流动 预处理 ATP 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学]