癫痫宁片治疗癫痫的随机双盲临床研究  

The Clinical Randomized Double-blinded Study on Therapeutic Effect of Diancianning Pian to Patients with Epilepsy

作　　者：甄瑾[1] 李润今[1] 王梅玲 张艳梅[1] 郭力军[1] 王文兰[1] 

机构地区：[1]内蒙古自治区医院神经内科儿科,内蒙古呼和浩特010017 [2]内蒙古国际蒙医院,内蒙古呼和浩特010018

出　　处：《内蒙古医学杂志》2010年第8期904-908,共5页Inner Mongolia Medical Journal

摘　　要：目的：观察癫痫宁片添加治疗强直-阵挛性癫痫发作的临床疗效。方法：收集我院2007年4月~2008年4月门诊及住院的69例强直-阵挛性发作癫痫患者,既往脑电图明确诊断为癫痫,近3月至少有两次发作,采取随机双盲方法,在应用原抗癫痫药物的基础上添加癫痫宁片或安慰剂,治疗3个月,每月记录1次患者的发作情况。治疗组46例,对照组23例,实验结束后作统计学分析及安全性评价。结果：癫痛宁片添加治疗癫痫,严重程度明显减轻,发作频率明显减少,伴随症状明显好转,用药期间无明显的毒副作用,耐受性良好。结论：癫痫宁片添加治疗强直-阵挛性癫痫发作具有较好疗效,不良反应少。Objective：To investigate the clinical effect of Dianxianning pian to patients with epilepsy.Method：In this double-blind,randomized clinical trial,69 patients with generalized tonic-clonic seizures were selected from clinic or department of neurology in Inner Mongolia Hospital from April 2007 to April 2008.They had been made a definite diagnosis by Electroencephalogram and had at least two seizures in previous three months.They were treated with Dianxianning pian or placebo for 3 months,based on previous anti-epileptic drug.We recorded and observed clinical symptoms each month.Data was analyzed and safety evaluation was gived by SPSS 13.0 statistic software at last.Result：46 subjects received Dianxianning pian and 23 received placebo.After 3 months therapy.the seizure frequency of experiment group was significantly decreased compared with control group（P0.01）.The severity of seizures total scores were significantly decreased compared with control group（P0.01）.Therapeutic effect of seizure frequency and therapeutic effect of symptom had significant difference befween the two groups（P0.01）.Safety index such as ECG,blood routine,urine routine,blood biochemical change had no statistically difference between the two groups（P0.05）.Conclusion：Add-on Dianxianning pian can raise therapeutic effect in patients with epilepsy of generalized t tonic-clonic seizures.And Dianxianning pian treatmentEpileptic seizures is safe and well tolerated.

关 键 词：癫痫 癫痫宁片 马蹄香 石菖蒲 

分 类 号：R742.1[医药卫生—神经病学与精神病学]