磷酸可待因片包衣前后溶出曲线比较  

The Compare of Dissolution Curves Between Before and After Coating Thin-film of Phosphate Codeine Tablets

作　　者：陈华[1] 

机构地区：[1]中国药品生物制品检定所,北京100050

出　　处：《中国药事》2010年第10期985-988,共4页Chinese Pharmaceutical Affairs

摘　　要：目的本文通过对磷酸可待因薄膜片包衣前后的溶出曲线的比较,介绍了溶出曲线比较的基本方法。方法分别采用了直观描述法、f值法、ANOVA法与模型法对溶出曲线进行了比较。结果根据直观描述法和f值法得出包衣前后溶出曲线未发生改变的结论。结论不同比较方法之间存在差异,应根据需求适当选择比较方法。Objective To introduce the methods of comparing dissolution curves by comparing the dissolution curves between before and after coating thin-film of phosphate codeine tablets.Methods Use description,f value,ANOVA and model-depended methods to compare the dissolution curves.Results There is no distinct difference between before and after coating thin-film of phosphate codeine tablets based on description and f value methods.Conclusion There is some diversity in different methods so as to select proper method based on requirement.

关 键 词：磷酸可待因 溶出度 溶出曲线 

分 类 号：R927.14[医药卫生—药学]