氧化应激与心室重构：氧自由基-MAPK-NF-κB信号转导通路  

Oxidative stress and cardiac re modeling： ROS-MAPK-NF-κB signal transduction pathway

作　　者：左友梅[1] 高杉[2] 张野[1] 

机构地区：[1]安徽医科大学第二附属医院麻醉科,合肥230601 [2]安徽医科大学基础医学院药理学教研室

出　　处：《国际麻醉学与复苏杂志》2010年第5期459-461,481,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金资助项目（30672032）;安徽省优秀青年基金资助项目（8040106814）;安徽医科大学博士科研经费资助项目（XJ200709）

摘　　要：心室重构（cardiac remodeling，CR）是多种因素导致的心脏结构和功能的改变，并是心血管疾病预后的主要预测因子。氧化应激是体内氧自由基产生和清除的动态平衡破坏后，氧自由基蓄积对机体造成的一种病理状态。近年来很多研究显示氧化应激参与CR的发生发展。现就氧化应激导致CR的部分信号转导通路作一综述。Cardiac remodeling is the change in the geometric structure and function of the left ventricle as a result of many factors, and the extent of left ventricular remodeling is an independent predictor of prognosis of the patients with cardiovascular diseases. Oxidative stress occurs when excess reactive oxygen species （ROS） are generated and cannot be adequately countered by intrinsic antioxidant systems. Excessive ROS generation triggers cell dysfunction, lipid peroxidation and DNA mutagenesis and can lead to irreversible cell damage or death. Recent studies revealed that increases of oxidative stress have been implicated in the development of cardiac remodeling. In this review, we discuss the partial signaling pathways between oxidative stress and cardiac remodeling.

关 键 词：氧化应激 心室重构 信号转导 

分 类 号：R363[医药卫生—病理学]