肿瘤:一种蛋白质组病  

Cancer:a Proteomic Disease

作　　者：李国庆[1,2] 肖哲锋[1] 刘健平[1] 李萃[1] 李峰[1] 陈主初[1] 

机构地区：[1]中南大学湘雅医院,卫生部肿瘤蛋白质组学重点实验室,长沙410008 [2]南华大学药学与生命科学学院生物科学系,衡阳421001

出　　处：《中国科学：生命科学》2010年第9期788-794,共7页Scientia Sinica(Vitae)

基　　金：国家重点基础研究发展计划(批准号:2001CB510207);国家自然科学基金(批准号:30800419;30973289;30972970);教育部新世纪人才支持计划(批准号:NCET-07-0861)资助项目

摘　　要：恶性肿瘤的发生是一个涉及多因素、多基因的多阶段病理过程.以往的研究主要集中在基因组和转录组分析.随着人类基因组计划的完成,肿瘤研究开始进入"后基因组时代",肿瘤蛋白质组学应运而生.蛋白质作为基因功能的主要执行者,一方面在肿瘤发生发展过程中扮演重要角色,另一方面在很大程度上决定正常细胞和肿瘤细胞之间的差异(如异型性、恶性特征等).本文提出,肿瘤是一种蛋白质组病,并根据肿瘤比较蛋白质组、表达蛋白质组、功能蛋白质组和结构蛋白质组研究进展,从肿瘤发生发展过程中蛋白质(组)表达水平及状态、蛋白质翻译后修饰、蛋白质相互作用及网络调控等三个方面进行阐述.该观点的提出,将为肿瘤发病机制的研究开辟新的领域,为肿瘤的诊断(如生物标志物筛选)和筛选(如药物新靶标)提供新的思路,具有重要的科学意义和临床应用价值.The development of cancer is a pathological process involving multiple environmental carcinogenic factors and multiple genetic alterations in multiple steps. For the past decades, cancer researches have been focused on the genomic and transcriptomic analysis. The completion of the Human Genome Project has opened the door to the Post-Genome Era and oncoproteomics emerges as the times require. As the major direct executors of the gene functions, proteins play a critical role in tumorigenesis and determine the differences between normal cells and malignant cells including heterogeneity and malignant properties. This report first proposed the idea that cancer is a proteomic disease. The idea was elucidated following the aspects： protein expression profiling,post-translational modifications in proteins,protein-protein interactions and regulation of the interaction network in carcinogenesis based on the recent advances of expression proteomics, comparative proteomics, functional proteomics and structural proteomics. The idea provides a new way of looking at carcinogenesis, presents new clues in biomarker discovery for cancer diagnosis and therapy, and displays the great scientific significance and clinical application value.

关 键 词：肿瘤 蛋白质组病 蛋白质表达谱 翻译后修饰蛋白质组 蛋白质相互作用 

分 类 号：R730.2[医药卫生—肿瘤]