Ⅰ/Ⅱ期子宫内膜癌术后放射治疗疗效分析  

Outcomes of postoperative radiotherapy in early endometrial carcinoma

作　　者：朱丽红[1] 王俊杰[1] 曲昂[1] 田素青[1] 王皓[1] 

机构地区：[1]北京大学第三医院肿瘤治疗中心,北京100083

出　　处：《现代肿瘤医学》2010年第10期2033-2036,共4页Journal of Modern Oncology

摘　　要：目的:评价Ⅰ/Ⅱ期子宫内膜癌术后放疗的疗效和并发症。方法:2001年9月-2008年8月收治45例Ⅰ/Ⅱ期子宫内膜癌术后患者。采用常规4野等中心适形照射技术,全盆腔6-10MV-X,DT46-50Gy/23-25 f/31-35d,2Gy/f,5 f/w。结果:中位随访50个月,1年、3年和5年总生存率分别为1 0 0%、96.9%和88.9%,1年、3年和5年无病生存率分别为93.2%、84.2%和84.2%。1年、3年和5年局部控制率分别为97.8%、94.6%和94.6%。1年、3年和5年远处转移率分别为6.7%、12.3%和12.3%。45例患者的急性反应主要是1例4°WBC减少症,3例3°腹泻。14例行盆腔淋巴结清扫术患者出现晚期并发症,其中3例为肠梗阻,2例3°,1例5°。结论:术后放疗可以降低有高危因素的早期子宫内膜癌的局部控制率,但晚期放射损伤发病率相对较高。Objective：To assess locoregional control,disease free survival,and overall survival and complications in patients treated with postoperative radiotherapy for early endometrial carcinoma.Methods：From 2001 to 2008,45 patients with stage Ⅰ/Ⅱ endometrial cancer received conventional whole pelvis irradiation of four radiation fields with a total dose of 46-50 Gy/23-25f/31-35d,2Gy/f,5f/w.Results：Over a median follow-up of 50 months（range10-93）,1-year,3-year and 5-year overall survival rates were 100%,96.9% and 88.9% respectively,disease-free survival rates were 97.8%,84.2% and 84.2% respectively,locoregional control rates were 97.8%,94.6% and 94.6% respectively,distant metastasis rates were 6.7%,12.3% and 12.3% respectively.Late radiation induced damage occured in 14 patients which received pelvic lymph node dissection,included 3 small bowel obstruction and 1 patient died.Conclusion：Postoperative RT in early stage endometrial carcinoma decreases the risk of recurrence,but has relatively high frequency of late radiation injury.

关 键 词：子宫内膜癌 放射治疗 早期病变 

分 类 号：R737.33[医药卫生—肿瘤] R730.55[医药卫生—临床医学]