CDIC和ITI纯钛种植体周围骨组织生物学基础研究  

Biological research of the bone formation around CDIC and ITI titanium implants

作　　者：姜玲[1] 金东春[2] 张晓燕[1] 孙培江[1] 黎卫星[1] 金光春[1] 

机构地区：[1]滨州医学院,山东烟台264003 [2]延边大学,吉林延吉133000

出　　处：《临床口腔医学杂志》2010年第8期451-453,共3页Journal of Clinical Stomatology

基　　金：山东省自然科学基金重点项目(Z2006C01)

摘　　要：目的:应用MicroCT、光学显微镜评价国产CDIC和ITI纯钛种植系统与周围骨组织整合的差别。方法:拔除狗的第一、第二磨牙,4个月后应用国产CDIC和ITI种植体植入,同体对照,术后4月、12月处死动物,分别取含种植体的组织块,MicroCT成像建立三维模型后,不脱钙切片甲苯胺蓝染色行光学显微镜对比观察。结果:①.两组种植体均被机体耐受,周围的骨组织均未发现炎症细胞和巨大细胞②.MicroCT、光学显微镜观察均显示ITI比CDIC种植体新骨形成早、量多,一年之后两者骨组织形成量没有显著差别。③MicroCT和光学显微镜对种植体周围骨组织微结构的研究结果具有正相关性。结论:使用国产CDIC种植系统与ITI种植系统骨结合基本相同,在临床上能获得较高的成功率。MicroCT分辨率高,能够建立高清晰三维图像,是对种植体周围骨组织研究的一种准确有效的新方法。Objective：Using Micro CT and optical microscope to compare bone formation adjacent to newly product CDIC implant（CDIC,Homemade,China）with ITI implant（Sweden）surface. Method：CDID and ITI were implanted in the regions of molars of the dogs,seperately,the same body control. 4 months and 12 months after operation,bone formations were evaluated respectively through optical microscope（undecalcified section,toluidine blue staining）and 3D Micro CT observation. Result：①.In the microscopic studies,neither infiltration of inflammatory cells nor the giant cells were observed on both groups. ②.Through the observations of optical microscope and 3D Micro CT,new bone formation around ITI implant were more and earlier than CDIC.Both have no distinct difference after one year.③.The observation results were no significant difference by optical microscope and 3D Micro CT. Conclusion：Comparing with ITI implant,CDIC implant made of CP grade titanium showed similar good bone healing,formation osseointegration.Micro CT is a new and efficient method for morphometric analysis of the bone formation around bonecontact.

关 键 词：光学显微镜 MICROCT 周围骨组织 CDIC ITI 纯钛种植体系统 

分 类 号：R782.1[医药卫生—口腔医学]