免疫组织化学法在口腔黏膜白色病变病理诊断中的意义研究  

The research of immnunohistochemistry in the pathologic diagnosis of white lesions of oral mucosa

作　　者：裴婧[1] 卓夏阳[1] 贾云香[1] 

机构地区：[1]南昌大学医学院附属口腔医院病理科,江西南昌330006

出　　处：《临床口腔医学杂志》2010年第8期454-457,共4页Journal of Clinical Stomatology

摘　　要：目的:研究免疫球蛋白(Ig)和补体(C)在口腔扁平苔藓(OLP)、盘状红斑狼疮(DLE)和慢性增殖型念珠菌病(CHC)中的表达,以期找出对口腔黏膜白色病变有辅助检查意义的更简便、有效的方法。方法:运用免疫组织化学非生物素二步法对OLP、DLE和CHC进行检测,并将结果进行统计学分析。结果:免疫组织化学染色显示免疫复合物在三组基底膜区和结缔组织中单核细胞的阳性表达率有统计学差异(P<0.05)。DLE组的基底膜区有免疫复合物的多元沉积。结论:运用免疫组织化学非生物素二步法检测Ig和C在口腔黏膜白色病变中的表达对其鉴别诊断有一定的辅助意义。Objective： To study the expression of immunoglobulins and complement in tissues of oral lichen planus, discoid lupus erythematosus and chronic hyperplastic candidiasis, to find easier and more effective methods which adjunctively examining white lesions of oral mucosa. Method： Immunohistochemistry （non-biotin） was applied to detect oral lichen planus, discoid lupus erythematosus and chronic hyperpiastic candidiasis, and the data was analyzed with statistical program. Result： There were obvious differences of immunocomplex positive rate in the BMZ and the histomonocytes in the connective tissue of the three groups （P 〈0.05）, IgG, IgM, IgA, （or） C3 deposited at the BMZ of DLE group. Conclusion： There is an assistant meaning in differential diagnosis of white lesions of oral mucosa by applying immunohistochemistry to detect the immunoglobulins and complement.

关 键 词：口腔扁平苔藓 盘状红斑狼疮 慢性增殖型念珠菌病 免疫组织化学 

分 类 号：R781.5[医药卫生—口腔医学]