乳腺癌患者血清中核因子-κB的检测及临床价值  

Detection of NF-κB expression in sera of patients with breast cancer and its clinical value

作　　者：李志国[1,2] 董学君[2] 孙红刚[1] 卢韬[1] 

机构地区：[1]温州医学院,浙江温州325035 [2]浙江省绍兴市人民医院分子医学中心,浙江绍兴312000

出　　处：《中国卫生检验杂志》2010年第10期2407-2408,2411,共3页Chinese Journal of Health Laboratory Technology

基　　金：绍兴市科技计划项目(2009A23005);浙江省医药卫生科学研究基金(2009A208)

摘　　要：目的:探讨乳腺癌患者血清中核因子-κB(NF-κB)表达水平及其在乳腺癌的诊断、转移和复发中的应用价值。方法:NF-κB ELISA试剂盒检测乳腺癌、乳腺良性肿瘤患者以及体检正常女性血清中NF-κB的浓度。结果:与正常对照组比较,乳腺癌患者血清中NF-κB的浓度升高(P<0.05),良性对照组与正常对照组比较没有差别(P>0.05)。Ⅲ和Ⅳ期乳腺癌患者比Ⅰ和Ⅱ期乳腺癌患者血清中NF-κB的浓度表达高(P<0.05);已发生腋窝淋巴结转移的乳腺癌患者比未发生腋窝淋巴结转移的乳腺癌患者血清NF-κB浓度高(P<0.05);术后1年乳腺癌复发的患者血清中NF-κB的浓度比未复发的患者血清中的表达高,存在明显差异(P<0.05)。结论:血清NF-κB的表达与乳腺癌的发生、转移和复发密切相关,可能成为较理想的乳腺癌肿瘤标志物。Objective：To detect NF-κB expression in sera of patients with breast cancer and to evaluate their value on diagnosis,metastasis,recurrence after Surgery.Methods： Apply NF-κB ELISA kit to detect NF-κB concentrationin sera of breast cancer patients,benign breast disease patients and healthy women.Results： The NF-κB concentration in sera of？ patients with breast cancer were higher than the healthy women（P0.05）,it was found that no difference existed in the concentration of NF-κB between in benign breast disease patients and healthy women（P0.05）.The NF-κB expression in breast cancer with TNM stage（Ⅲ＋Ⅳ） were higher than those of TNM stage（Ⅰ＋Ⅱ）（P0.05）.The NF-κB expression in breast cancer patients with axillary lymph node metastasis were higher than those without axillary lymph node metastasis.The NF-κB expression in patients with breast cancer recurrence after 1 year were higher than those without recurrence（P0.05）.Conclusion： The NF-κB expression in sera is closely correlated with presence,metastasis,recurrence of breast cancer,it may be used as the tumor mark of breast cancer.

关 键 词：乳腺癌 NF-ΚB 转移 复发 

分 类 号：R737.9[医药卫生—肿瘤]