CTVP与CTOP方案治疗280例非霍奇金淋巴瘤临床疗效分析  

Comparison of the Therapeutic Effects of CTVP and CTOP Regimens as Initial Treatment for Non-Hodgkin's Lymphoma

作　　者：侯芸[1] 王华庆[1] 付凯[1] 刘贤明[1] 张会来[1] 钱正子[1] 李兰芳[1] 周世勇[1] 崔秀珍[1] 郝希山[1] 

机构地区：[1]天津市肿瘤防治重点实验室 天津医科大学附属肿瘤医院淋巴肿瘤科 中美淋巴血液肿瘤诊治中心,天津市300060

出　　处：《中国肿瘤临床》2010年第18期1065-1068,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:比较含长春地辛(VDS)的CTVP方案与含长春新碱(VCR)的CTOP方案治疗初治非霍奇金淋巴瘤(NHL)的近期疗效、远期生存及不良反应。方法:采用两种方案治疗初治NHL患者共280例,CTVP组162例,CTOP组118例。结果:两组患者临床特征指标相似(P>0.05)。可评价疗效272例,两组有效率分别为73.13%和72.32%,临床获益率分别为91.88%和90.18%(P>0.05)。骨髓抑制、胃肠道反应、乏力、外周神经毒性和脱发为主要不良反应。CTVP组外周神经毒性的发生率低于CTOP组(14.81%:31.36%,P<0.05)。中位随访时间32个月(2～71个月),两组5年生存率分别为43.2%和22.3%(P<0.05)。结论:采用含VDS的CTVP方案治疗初治NHL疗效较好,毒性较低,远期生存率较高,值得临床进一步研究。Objective： To compare the efficacy and toxicity of CTVP （with VDS） and CTOP （with VCR） regimens as an initial treatment for Non-Hodgkin Lymphoma. Methods： From January 2000 to December 2005, 288 patients with Non-Hodgkin Lymphoma were treated in Tianjin Cancer Hospital with combined chemotherapy, including CTVP and CTOP, among which 162 were treated by CTVP and 118 by CTOP regimen. The rate of response, toxicity and long-term survival for the 2 regimens were analyzed retrospectively. Results： The clinical characteristics of the 2 groups were quite similar （P〉0.05）. A total of 272 patients were eligible. The response rates for CTVP and CTOP were 73.13% and 72.32%, the clinical benefit rates were 91.88% and 90.18%, respectively （P〉0.05）. Major toxicity was myelosuppression, GI toxicity, fatigue, neurotoxicity and alopecia. Incidence of neurotoxicity was lower in the CTVP group than in the CTOP group （14.81% vs. 31.36%, P〈 0.05）. Median follow-up was 32 months （ranging from 2 to 71 months）. The 5-year overall survival rates for the CTVP and CTOP groups were 43.2% and 22.3%, respectively （P〈0.05）. Conclusion： VDS in the CTVP regimen may be more effective as an initial treatment for Non-Hodgkin lymphoma, with lower toxicity and better long-term survival. A randomized clinical trial is required to confirm these results.

关 键 词：非霍奇金淋巴瘤 长春地辛 长春新碱 吡喃阿霉素 

分 类 号：R733.1[医药卫生—肿瘤]