正交试验优选紫参片的醇提工艺  

Optimization of Ethanol Extract Technology for ZiShen Tablet by Orthogonal Test

作　　者：崔雪娜[1] 王四旺[1] 赫少清[1] 王剑波[1] 党碧艳[1] 

机构地区：[1]第四军医大学药学系药物研究所,陕西西安710032

出　　处：《现代生物医学进展》2010年第18期3544-3546,共3页Progress in Modern Biomedicine

摘　　要：目的:优选紫参片的醇提工艺。方法:以醇浸膏得率、丹参酮ⅡA、阿魏酸含量为考察指标,采用正交试验法,考查乙醇浓度、加醇量及提取时间对紫参片提取工艺的影响。结果:最佳醇提工艺为A2B2C2,即药材加6倍量70%乙醇提取3次,每次提取1h。结论:优选的紫参片的醇提工艺简便、快速、准确,可为工业化生产提供理论依据。Objective：To optimize the ethanol extract technology of ZiShen tablet.Methods：Alcohol extract rate,salviol and ferulaic acid content were chosen as the indexes for investigation and orthogonal test was carried out to investigate the effects of three ext-racting factors（alcohol density,alcohol amount and extracting time）on the extract technology.Results：The optimum extract technolo-gy was A2B2C2,it is adding 70% alcohol which was 6 times the quantity of medicine and extracting twice（one hour each time）.Conclu-sions：The optimized ethanol extract technology for ZiShen tablet is simple,rapid and accurate and serves as theoretic basis for the indus-trialized production of this preparation.

关 键 词：正交试验 紫参片 醇提工艺 丹参酮IIA 阿魏酸 

分 类 号：R285[医药卫生—中药学]