代谢组学及其在法医学中的应用展望  

Metabonomics and Its Perspective on Forensic Medicine

作　　者：张高勤[1] 王玫[2] 张大明[2] 刘耀[3] 

机构地区：[1]中国人民公安大学,北京100038 [2]北京市公安局法医检验鉴定中心,北京100085 [3]公安部物证鉴定中心,北京100038

出　　处：《法医学杂志》2010年第5期374-380,共7页Journal of Forensic Medicine

基　　金：公安部重点研究计划项目(2009ZDYJBJSJ001)

摘　　要：代谢组学是运用色谱、质谱、核磁共振(NMR)、毛细管电泳(CE)等技术对细胞、体液和器官等样品中的代谢物进行分离、纯化和检测,再用生物信息学的手段对所获得数据进行分析处理,从而得到一个或一组生物标记物信息的一门新兴学科。本文通过分析近年来有关代谢组学研究的文献报道,从历史渊源、概念、优点、分析方法、应用研究、存在问题及发展机遇、专业期刊和网站等方面对其进行综述,并根据现有研究对其在法医学各专业的应用作以展望,相信其能为法医学各专业和法医学鉴定提供一条新的研究思路。Metabolomics is a new study,which use chromatography,mass spectrometry,nuclear magnetic resonance（NMR）,capillary electrophoresis（CE） techniques on the cells,organs and other body fluids and metabolites in samples were isolated,purified and testing,re-use bioinformatics tools on the obtained data are analyzed to obtain one or a set of biomarker information.Based on analysis of the literatures in recent years,metabolomics was summarized from history,concept,advantage,methods,application,difficulties and challenges,journals and books,websites,and its application in forensic medicine was forecasted.As a new branch of global system biology,metabonomics developed rapidly,and its perspective on forensic medicine was feasible and very optimistic.

关 键 词：法医毒理学 代谢组学 综述[文献类型 

分 类 号：R151[医药卫生—营养与食品卫生学]