血清TGAb的测定在分化型甲状腺癌中的作用  

The Clinical Application of Measurement of Serum Thyroglobulin Antibody in Differentiated Thyroid Cancer

作　　者：李跃松[1] 戴军[1] 陈永伟[1] 朱亚妮[1] 

机构地区：[1]江苏省原子医学研究所附属江原医院检验科,江苏无锡214063

出　　处：《标记免疫分析与临床》2010年第5期296-298,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨在电化学发光免疫法测定TG时TGAb对其测定的影响及TGAb在分化型甲状腺癌(DTC)患者中的阳性分布情况。在一高浓度的TGAb血清中加入一定量的高浓度TG(试剂R3),测定TG的回收率,并对74例DTC患者在术前及术后一个月分别进行TG和TGAb的测定。结果显示,TGAb的浓度在2840.20～81.15IU/mL之间时,TG的回收率在73.99%～93.34%之间,TG的回收率同TGAb的浓度呈负相关(r=-0.9909,P<0.01);TGAb在DTC患者中的阳性率为29.7%,其中以乳头状癌伴桥本甲状腺炎组为最高(56.5%)。结论:在用电化学发光免疫法测定TG时TGAb会对其产生负干扰,并呈浓度依赖性,且TGAb在DTC患者中存在一定的阳性率,这应引起临床的重视,以防发生错误的临床诊断。To investigate the interference of serum thyroglobulin antibody（TGAb） measurement by electrochemiluminescence immunoassay（ECLIA）,the serum TG and TGAb in 74 cases of patients with differentiated thyroid cancer（DTC） pre-operation and after one month of operation were measured,the recoveries of TG were determined in serum samples with different concentrations of TGAb.The results showed that the TG recovery rate was 73.99%～93.34% with different concentrations of TGAb（2840.20-81.15IU/mL）.The TG recovery rate was negatively correlated with TGAb concentrations（r=-0.9909,P0.01）.The positive rates of serum TGAb in DTC patients were 29.73%.The positive rates in papillary carcinoma combination with Hashimoto＇s thyroiditis were 56.52%.The serum TGAb will cause some negatively interference in the measurement of TG by ECLIA.

关 键 词：分化型甲状腺癌 甲状腺球蛋白 甲状腺球蛋白抗体 电化学发光免疫法 

分 类 号：R736.1[医药卫生—肿瘤]