VEGF-C、D2-40在结肠直肠癌的表达及其临床意义  

The expression of VEGF-C and D2-40 in colorectal cancer and its significance

作　　者：周艳萍[1] 陈萍[1] 韩颖[1] 张伟东[1] 巩雷[1] 

机构地区：[1]吉林省吉林市中心医院病理科,132011

出　　处：《中国临床研究》2010年第10期856-857,共2页Chinese Journal of Clinical Research

摘　　要：目的探讨血管内皮生长因子C(VEGF-C)、淋巴管内皮细胞特异性标记物D2-40与结肠直肠癌淋巴结转移的关系。方法 56例结肠直肠癌患者中有淋巴结转移30例,无淋巴结转移26例。应用免疫组织化学染色方法检测肿瘤原发灶的VEGF-C、D2-40的表达情况。结果 56例结肠直肠癌患者中有、无淋巴结转移者的VEGF-C阳性表达率分别为73.3%、15.4%,两者比较,差异有统计学意义(P<0.05);有、无淋巴结转移者D2-40标记的淋巴管密度分别为33.2±2.3、21.4±1.6,两者比较,差异有统计学意义(P<0.05)。结论结肠直肠癌患者癌组织中VEGF-C、D2-40的表达与淋巴结转移相关。Objective To study the relation between vascular endothelial growth factor C （VEGF-C）, D2-40 and lymph node metastasis in colorectal cancer and its clinical significance. Methods Among 56 cases of colorectal cancer,30 cases had lymph node metastasis （ metastasis group）, and 26 cases had not lymph node metastasis （ no metastasis group）. The samples were taken in the site of primary tumor, and the preparations were processed by 4% formaldehyde fixation, paraffin embedding, sectioning and SP staining. The expressions of VEGF-C and D2-40 were detected by immunohistochemical SP method. The positive expression rate of VEGF-C and D2-40 labeled lymphatic microvessel density were calculated. Results VEGF-C positive exprcssion rate in metastasis group was significantly higher than that in no metastasis group （73.3% vs 15.45% ,P 〈 0. 05）. D2-40 labeled lymphatic microvessel density in metastasis group was significantly higher than that in no metastasis group （33.2 ± 2. 3 vs 21.4± 1.6, P 〈 0. 05 ）. Conclusions The expressions of VEGF-C and D2-40 are associated with lymph node metastasis of colorectal cancer.

关 键 词：血管内皮生长因子C D2-40 结肠直肠癌 淋巴结转移 免疫组化 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]