奥美拉唑联合呋喃唑酮根除幽门螺杆菌的疗效观察  

Clinical effect of dual Therapy of omeprazol plus furazolidone for eradication of Helicobacter pylori

作　　者：孙嘉丽[1] 刘厚钰[1] 张希德[1] 张顺财[1] 

机构地区：[1]上海医科大学附属中山医院

出　　处：《胃肠病学和肝病学杂志》1999年第2期120-123,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）是慢性胃炎、消化性溃疡的主要致病因素之一。本研究旨在通过对奥美拉唑（ＯＭＥ）和呋喃唑酮（ＦＺ）联合用药的疗效观察以寻求一种有效、方便的疗法。方法病例选择：经胃镜检查确诊的慢性胃炎或十二指肠球部溃疡且Ｈｐ检测阳性的患者，经过纳入标准及排除标准的筛选而进入研究。分组治疗：病例随机分为三个治疗组，治疗组１（２３人）：ＯＭＥ２０ｍｇｑｄ＋ＦＺ０．２ｇｂｉｄ；治疗组２（２５人）：ＯＭＥ２０ｍｇｑｄ＋ＦＺ０．２ｇｔｉｄ；治疗组３（２６人）：ＯＭＥ２０ｍｇｂｉｄ＋ＦＺ０．２ｇｔｉｄ，疗程均为７天。其中十二指肠球部溃疡病人ＯＭＥ按各自剂量再服一周。停药四周后做１３Ｃ－尿素呼气试验。结果７４例患者进入研究。治疗组１有２２人完成全疗程，根除率８６４％；治疗组２为１８人，根除率８３３％；治疗组３为１９人，根除率７８９％。治疗组２、３（ＦＺ０２ｇｔｉｄ）与治疗组１（ＦＺ０２ｇｂｉｄ）之间根除率的差异无显著意义，但不良反应发生率明显增加。结论本研究显示方案一不良反应发生率低，依从性好，疗效达到８６４％；依从性是影响根除率高低的重要因素；体外试验显示Ｈｐ对呋喃唑酮?Aim Helicobacter pylori(Hp) is one of the main pathogenic factors of chronic gastritis and peptic ulcer.This study is to evaluate the clinical effect of dual therapy of OME (omeprazol)plus FZ(furazolidone) and consequently to find an effective and convenient medication for eradication of Hp. Methods Patients: The Hp postitive patients with chronic gastritis or duodenal ulcer confirmed by gastroscopy were enrolled in this research according to the eligibility criteria. Intervention: Totally 74 patients were finally selected and randomly allocated into 3 groups.The 7-day medication for Group 1(23 cases )was OME 20 mg qd+FZ 0.2 g bid,Group 2(25 cases) OME 20 mg qd+FZ 0.2 tid and Group 3 (26 cases)OME 20 mg bid+FZ 0.2 tid.The patients with duodenal ulcer took OME for one more week.The 13C-urea breath test for Hp infection was performed 4 weeks after the end of intervention. Results There were finally 22 patients in Group 1 who completed the interventional protocol,18 in group 2,and 19 in group 3.Comparing with the eradication rate of 86.4% of Group 1, the eradication rates of Group 2 and 3(83.3% and 78.9% respectively)has no significant difference;however,the adverse-effect rates of the latter two(32.0% and 23.1%,respectively)were much higher than that of Group 1(8.7%).HZ]Conclusion It showed that the therapy of OME 20 mg qd+FZ 0.2 bid could achieve the Hp eradication rate of 86.4% with low adverse-effect rate and good compliance.It was also found that the compliance was important for the eradication of Hp.The Hp strains in this research were all sensitive for FZ.

关 键 词：幽门螺杆菌 奥美拉唑 呋喃唑酮 胃炎 消化性溃疡 

分 类 号：R573.105[医药卫生—消化系统] R573.305[医药卫生—内科学]