MRI和骨扫描对乳腺癌骨转移诊断价值的Meta分析  

Diagnostic Value of MRI versus Bone Scan for Osseous Metastasis in Breast Cancer: A Meta-analysis

作　　者：李芸芝[1,2] 马彬[1] 杨克虎[1,2] 周怀琪[1,2,3] 

机构地区：[1]兰州大学循证医学中心,兰州大学基础医学院,兰州730000 [2]兰州大学第一临床医学院,兰州730000 [3]兰州大学第一医院,兰州730000

出　　处：《中国循证医学杂志》2010年第10期1159-1163,共5页Chinese Journal of Evidence-based Medicine

基　　金：兰州大学循证医学中心"循证医学创新项目"(2009LDEBM-A);兰州大学中央高校基本科研业务费专项资金资助(Lzujbky2009-t12)

摘　　要：目的评价MRI和骨扫描对乳腺癌骨转移的诊断价值。方法检索PubMed、EMbase、Cochrane图书馆、CBM、CNKI和VIP等数据库,按照诊断试验的纳入标准筛选关于MRI和骨扫描对乳腺癌骨转移诊断价值的诊断试验,采用QUADAS条目评价纳入研究的方法学质量,并采用Meta-Disc1.4软件进行Meta分析,绘制汇总受试者工作特征曲线(SROC曲线),计算曲线下面积。结果共纳入5个研究包括329例研究对象,MRI与骨扫描的敏感度分别为0.99[95%CI(0.97,1.00)]、0.93[95%CI(0.88,0.97)];特异度分别为0.99[95%CI(0.95,1.00)],0.86[95%CI(0.79,0.92)];SROC曲线下面积分别为0.9936、0.9675。结论 MRI可以作为诊断乳腺癌骨转移有效、可行的方法。Objective To assess the diagnostic value of MRI and Bone Scan （BS） for osseous metastases in patients with breast cancer. Methods The trials were searched from PubMed, EMBASE, Cochrane Library, CBM, CNKI and VIP; the Criteria for inclusion and exclusion were based on the standard for diagnosis tests. Meta-Disc software （Version 1.4） was used for data analysis; and the area under curve （AUC） of SROC was calculated. Results A total of 5 researches involving 329 patients were included. The sensitivity of MRI and BS were 0.99 （0.97, 1.00） and 0.93 （0.88, 0.97） respectively; the speci city for MRI and BS were 0.99 （0.95, 1.00） and 0.86 （0.79, 0.92） respectively; and the AUC of SROC curve for MRI and BS were 0.9936 and 0.9675 respectively. Conclusion MRI can be regarded as an e ective and feasible method for osseous metastases in breast cancer.

关 键 词：乳腺癌 骨转移 磁共振成像 骨扫描 META分析 

分 类 号：R737.9[医药卫生—肿瘤]