环氧化酶-2、Livin在结直肠癌组织中的表达研究  

Expression of COX-2 and Livin in colorectal cancer

作　　者：林荣威 陈占海[1] 奚志强[1] 陈晓燕[2] 

机构地区：[1]天台县中医院外科,浙江天台317200 [2]天台县中医院病理科,浙江天台317200

出　　处：《全科医学临床与教育》2010年第5期490-492,共3页Clinical Education of General Practice

摘　　要：目的探讨环氧化酶-2(COX-2)、Livin在结直肠癌发生机制中的作用。方法通过免疫组织化学方法检测结直肠癌病理标本中(癌组织组)COX-2、Livin的表达情况,并与正常结直肠组织阴性对照组比较。结果癌组织组COX-2阳性表达率为81.08%(30/37),Livin阳性表达率为86.49%(32/37),对照组COX-2阳性表达率为2.70%(1/37),Livin阳性表达率为0%(0/37),癌组织组的COX-2、Livin表达率明显高于对照组,差异均有统计学意义(χ2分别=7.03、8.96,P均<0.05)。结直肠癌病理标本中COX-2、Livin的表达相关性,经Spearman等级相关分析为正相关(r=0.29,P<0.05)。结论结直肠癌的发生与组织细胞中COX-2、Livin的表达异常有关,阻断COX-2、Livin的异常表达是制止肿瘤细胞凋亡、增殖失控的关键。Objective To investigate the role of COX-2 and Livin in colorectal cancer mechanism.Methods COX-2 and Livin expressions in pathologic specimens of colorectal cancer（cancer group） were detected by immunohistochemistry,and compared with normal colorectal（negative control） group.Results In the cancer group,the positive expressions of COX-2 and Livin were 81.08%（30/37） and 86.49%（32/37）;in the control group,they were 2.70%（1/37） and 0%（0/37）,respectively.COX-2 and Livin expressions in cancer group were significantly higher than those in the control group（χ2=7.03,8.96,P0.05）.COX-2 and Livin expressions in pathologic specimens of colorectal cancer were positively correlated by analysis of Spearman rank correlation（r =0.29,P 0.05）.Conclusion The incidence of colorectal cancer is related to the abnormalities of COX-2 and Livin expressions in tissue cells;blocking the abnormal expressions of COX-2 and Livin is the key to stop tumor cell apoptosis and loss control of proliferation.

关 键 词：结直肠癌 环氧化酶-2 LIVIN 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]