氟伏沙明合并舒必利治疗有精神病性症状的抑郁症对照研究  

Fluvoxamine combined with Sulpiride in the treatment of depression with psycholic symptoms

作　　者：王爱荣[1] 李秀玲[1] 刘晓燕[1] 

机构地区：[1]山东省济宁市精神病防治院,济宁272051

出　　处：《精神医学杂志》2010年第5期345-347,共3页Journal of Psychiatry

摘　　要：目的探讨氟伏沙明合并舒必利治疗有精神病性症状抑郁症的临床疗效及安全性。方法将103例符合条件的患者随机分为氟伏沙明联合舒必利组(研究组)及单用氟伏沙明组(对照组),疗程8周。用4级临床疗效、HAMD、BPRS量表观察疗效,用TESS量表评定不良反应。结果治疗8周后2组BPRS、HAMD总分及因子分都较疗前明显降低,差异有显著性(P<0.01);氟伏沙明联合舒必利组痊愈率和显效率显著高于单用氟伏沙明,差异有显著性(P<0.05);研究组BPRS的思维障碍、激活性、敌对猜疑因子分和总分明显低于对照组,经t检验,差异有显著性(P<0.05);研究组HAMD的阻滞、体质量因子分和总分明显低于对照组,经t检验,差异有显著性(P<0.05)。结论氟伏沙明联合小剂量舒必利治疗有精神病性症状的抑郁症疗效优于单用氟伏沙明,不良反应少。Objective To explore the curative effect and safety of fluvoxamine combining sulpiride in the treatment of depression with psychotic symptoms. Method A total of 103 depressive patients with psychotic symptoms were randomly divided into fluvoxamine combined with sulpiride group （study group, n =52 ） or single fluvoxamine group（ con- trol group, n = 46 ） for 8 weeks. The Clinical efficacy, Hamilton Depression Rating Scale （HAMD） , Brief Psychiatric Rating Scale （BPRS） and Treatment Emergent Symptoms Scale （TESS） were used to evaluate efficacy and adverse effects. Results Compared with pretreatment, scores of the BPRS and HAMD in each week after treatment significantly decreased in two groups （P 〈 0.01 ）. The rates of recovery and markedly effeetion in study group were significantly high- er than that of control group. The total scores, factor scores of thought disorder, hostility and suspicious, activity of BPRS, and total scores, factor scores of inhibition and body weight of HAMD in study group were significantly lower than that of control grop. Conclusion Fluoxetine combining with low dose sulpiride would have better efficacy and fewer adverse effects than flunetive.

关 键 词：抑郁症 精神病性症状 氟伏沙明 舒必利 

分 类 号：R749.4[医药卫生—神经病学与精神病学]