四种非典型抗精神病药物对精神分裂症患者代谢综合征患病率的影响  

A comparative study of the prevalence of metabolism syndrome in schizophrenics patients treated with four atypical antipsychotics

作　　者：陶世武 杨诚 潘润德 潘天伟 李梁 

机构地区：[1]广西壮族自治区龙泉山医院精神科,柳州545005

出　　处：《精神医学杂志》2010年第5期365-367,共3页Journal of Psychiatry

基　　金：广西壮族自治区卫生厅科技研究计划课题(Z2007026)

摘　　要：目的探讨4种非典型抗精神病药物对精神分裂症患者代谢综合征患病率的影响。方法符合入组标准的360例精神分裂症患者随机分成4组,于治疗前和治疗后进行相关测定和实验室检查,代谢综合征的诊断标准采用2004年中华医学会糖尿病分会代谢综合征标准。结果利培酮组、喹硫平组、阿立哌唑组和齐拉西酮组的代谢综合征患病率分别为18.9%、14.4%、10.0%和6.7%。其中利培酮组与齐拉西酮组比较差异有统计学意义(P<0.05)。女性的患病率均高于男性。结论非典型抗精神病药物中利培酮和喹硫平对代谢综合征患病率有明显影响,阿立哌唑和齐拉西酮对代谢综合征患病率影响较小。Objective To study the influence of four atypical antipsychotics on the prevalence of Metabolism Syndrome（MS） in the treatment of schizophrenic patients. Methods Three hundred and sixty schizophrenic inpatients randomly were divided into risperidone group or quetiapine group or aripiprazole group or ziprasidone group. All the patients were tested before and after treatment. ResuLts The prevalence of MS in risperidone group, quetiapine group , aripiprazole group and ziprasidone group was 18.9% , 14.4% , 10.0% ,6.7% respectively, and the prevalence i.,ad significantly difference between risperdone group and ziprasidone group （P 〈 0.05）. The prevalence of MS in female was significant higher than that of male. Conclusion Risperidone and quatipine could effect the prevalence of MS markedly, but aripipazole and ziprasidone have smaller effects in the treatment of schizophrenia.

关 键 词：非典型抗精神病药物 精神分裂 症代谢综合征 患病率 

分 类 号：R749.3[医药卫生—神经病学与精神病学]