CXCL12/CXCR4生物学轴在泌尿系肿瘤中的研究进展  

Study Progress of CXCL12 and its Receptor CXCR4 in Urinary Tract Tumors

作　　者：王乙水[1] 杨旭升[1] 杨德林[1] 

机构地区：[1]昆明医学院第二附属医院泌尿外科,云南省泌尿外科研究所,昆明650101

出　　处：《医学综述》2010年第20期3072-3074,共3页Medical Recapitulate

基　　金：云南科技厅昆明医学院联合专项基金(2007C0016R);云南省应用基础研究基金(2008ZC135M)

摘　　要：趋化因子受体4(CXCR4)与其配体CXCL12结合组成的生物学轴具有高度特异性,在肿瘤细胞中广泛表达。对CXCL12/CXCR4生物学轴干扰可以影响肿瘤细胞的侵袭及转移,研究CXCL12/CXCR4生物学轴和泌尿系肿瘤之间的关系,可为泌尿系肿瘤的治疗开辟新的途径。现就CXCL12/CXCR4生物学轴与泌尿系肿瘤侵袭转移的关系进行综述。The biological axis consisting of cytokine receptor CXCR4 and its ligand CXCL12（stromal cell derived factor-1 SDF-1）has a high degree of specificity,which is widely expressed in tumor cells.The related studies showed that there was a close relation between CXCL12/CXCR4 axis and the invasion and metastasis of urinary tract tumors.The interference with the biological axis CXCL12/CXCR4 biology could affect the tumor invasion and metastasis,in a hope to find a new solution to tumor by disclosing the close relation.

关 键 词：CXCL12 CXCR4 肿瘤 

分 类 号：R737[医药卫生—肿瘤]