乳腺癌中DNA甲基化与ER和PR及HER-2表达的关系  

Correlation of DNA Methylation and the Expression of Estrogen Receptor,Progesterone Receptor,Human Epidermal Growth Factor Receptor 2 in Breast Cancer

作　　者：贾楠[1] 冯炜炜[1] 

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《医学综述》2010年第20期3075-3077,共3页Medical Recapitulate

摘　　要：DNA甲基化是人类基因组发生的最为常见的一种表观遗传学事件,在乳腺癌发生相关机制中具有重要意义。激素受体阳性和阴性的乳腺癌中DNA甲基化的模式和频率不同。DNA甲基化可能参与了三苯氧胺耐药的发生,也是提示预后的因素之一。研究乳腺癌相关基因异常甲基化与其雌激素受体、孕激素受体和人类表皮生长因子受体2表达的关系,有助于进一步明确乳腺癌的分子分型,指导诊断和临床预后,也有助于阐明内分泌治疗的耐药机制。DNA mehylation is one of the most common epigenetic events in human genome,and plays important role in breast cancer etiology.The methylation profiles and frequence vary in breast cancer with different hormone receptor status.DNA methylation is involved in tamoxifen resistence,and may be one of the prognostic factors.Research on correlation between aberrant DNA methylation profiles in breast cancer related genes and expression of estrogen receptor,progesterone receptor and human epidermal growth factor 2 contributes to molecular classification,diagnosis,prognosis and mechanisms of tamoxifen resistence in breast cancer.

关 键 词：乳腺癌 DNA甲基化 雌激素受体 孕激素受体 人类表皮生长因子受体2 

分 类 号：R737.9[医药卫生—肿瘤] R730.231.4[医药卫生—临床医学]