前颞海马杏仁核切除术后精神症状改变  

The change of psychiatric symptoms after Cortico-amygdalo-hippocampectomy in medial temporal lobe epilepsy patients by symptom check-list 90

作　　者：张光明[1] 周文静[1] 韩宏彦[1] 田宏[1] 张付全[2] 左焕琮[1] 

机构地区：[1]清华大学玉泉医院癫痫中心,北京100049 [2]清华大学玉泉医院精神科,北京100049

出　　处：《北京医学》2010年第10期782-784,共3页Beijing Medical Journal

基　　金：国家自然科学基金(2005CB522800;2004CB318101);首都医学发展科研基金(2009-3048)

摘　　要：目的探讨前颞海马杏仁核切除术式(CAH)对颞叶癫痫患者的精神症状的影响。方法 75例颞叶癫痫患者经历了CAH手术,并且3次(术前、术后1年、术后2年)顺利完成了SCL-90自评量表。统计分析患者的平均GSI(精神症状整体严重性)得分。结果患者术后1年和2年的平均GSI得分均低于术前。全体患者术后2年的平均GSI得分均低于术后1年。不同时期(术前、术后1年、术后2年)男女组之间,左右侧组之间以及头颅MRI正常和异常组之间的平均GSI得分均无显著性差异。结论 CAH术式可以改善颞叶癫痫患者术后的精神症状。这种改善与术后的疗效有关,而与性别、位置和MRI有无异常无关。Object To study the association between Corticoamygdalohippocampectomy （CAH, anterior temporal lobe resection plus amygdalohippocampectomy） and the change of psychological in TLE patients. Methods Seventy-five medial TLE patients who had CAH accomplished SCL-90 （Symptom Check-list 90） questionnaires three times （pre-surgical, post-surgical and two years after surgery）. Average GSI （global severity index） scores in SCL-90 were calculated and statistically analyzed. Results The average GSI scores of the whole group 1 and 2 years after surgery was statistically lower than that of the pre-surgery. The average GSI score of the whole group 2 years after operation was statistically lower than that of 1 year after surgery. There were no statistical differences between （male/female, right/left, normal MRI/abnormal MRI） subgroups in different time points （pre-surgical, one and two years after surgery）. Conclusion CAH could improve the psychiatric symptoms of TLE patients as assessed by the SCL-90. This improvement is related to the therapeutic effect and is not associated with gender, location, and MRI abnormality.

关 键 词：颞叶癫痫 前颞海马杏仁核切除术 精神症状 SCL-90量表 

分 类 号：R742.1[医药卫生—神经病学与精神病学]