解除颈动脉狭窄对认知功能影响的临床研究  

Clinical research of removing carotid stenosis on cognitive function.

作　　者：韦永胜[1] 肖军[1] 吴景芬[1] 陈祥慧[1] 冯群华[1] 

机构地区：[1]四川省人民医院神经内科,四川成都610072

出　　处：《四川医学》2010年第10期1410-1412,共3页Sichuan Medical Journal

基　　金：2008年度四川省卫生厅科研课题(编号:080336)

摘　　要：目的观察颈动脉狭窄解除后认知功能变化的情况。方法对已确诊的32例颈动脉狭窄的患者在支架安放术前及术后2周、3个月、半年行MOCA检查,观察其认知功能变化的情况。结果术前实验组与对照组MOCA得分相比有下降,差异有统计学意义,P<0.05,而术后6个月实验组与对照组比较仍然有降低,但差异无统计学P>0.05。在CAS实验组中,MOCA得分正常者(>26分),在术后的评分较术前有增高的趋势,但差异无统计学意义,P>0.05;MOCA得分异常者(≤26分),在术后2周时评分无明显改善,但在3个月,特别是6个月后评分有显著提高,差异有统计学意义,P<0.05。结论在解除颈动脉狭窄以后,由于脑血流灌注的增加,腔隙性脑梗死发生的减少,从而使认知功能得以改善。Objective The aim of this study was to observe the changed of cognitive function after carotid artery stcnosis been removed.Methods 32 patients with carotid artery stenosis were examined by MOCA to observe the changes of their cognitive function,before stent placement surgery,two weeks after the surgery,three month after the surgery,half-year after the surgery.Results Before the surgery,MOCA score did differ statistically between test group and control group（P0.05）.Six months after the surgery,MOCA score did not differ statistically between test group and control group（P0.05）.In the test group,scores of normal cases（MOCA score before surgery26）increased,but no significant statistical difference（P0.05）;In the same group,the scores of abnormal cases（MOCA score before surgery≤26）did not changed after 2 weeks,but the increase of score did differ statistically after 3months,especial after 6 months（P0.05）.Conclusion Blood flow in cerebral increased after the lifting of carotid stenosis,lead to reduction of lacunars infarction,then cognitive function of patients was improved.

关 键 词：颈动脉狭窄 认知功能 颈动脉支架置入术 蒙特利尔认知评估量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]