信号转导子和转录激活子3与其靶基因对食管鳞癌细胞的调控作用  

Control Function of Stat 3 and Its Target Genes for Esophageal Squamous Cell Carcinoma

作　　者：张建民[1] 刘惠民[2] 张咏梅[3] 时志民[2] 王蕾[2] 

机构地区：[1]河北省邯郸市第一医院外三科,056002 [2]河北工程大学医学院病理教研室 [3]河北工程大学成教学院

出　　处：《中国误诊学杂志》2010年第29期7062-7063,共2页Chinese Journal of Misdiagnostics

摘　　要：目的探讨信号转导子和转录激活子3及其靶基因对食管鳞癌细胞的调控作用。方法采用免疫组化方法检测60例食管鳞癌组织中Stat3、c-Myc和Bcl-2在蛋白水平的表达情况。结果食管鳞癌组织中Stat3、c-Myc和Bcl-2的表达均明显高于正常食管黏膜组(P<0.05);Stat3随着细胞的不断活化呈高表达。Stat3与c-Myc、Bcl-2的表达呈正相关(P<0.05)。结论 Stat3的持续性活化可能在食管癌变发生过程中起重要的调控作用。Objective To explore the control function of Stat 3and its target genes for esophageal squamous cell carcinoma.Methods To detect Stat3,c-Myc and Bcl-2,the expression in protein level of 60cases of esophageal squmous cell carcinoma by immunohistochemistry.Results The expression of Stat3,c-Myc and Bcl-2were all significantly higher in esophageal squmous cell carcinoma than that of the normal esophageal mucosa（P〈0.05）;Stat3 activation as the cell constant was highly expressed.Stat3and c-Myc,Bcl-2were positively related（P〈0.05）.Conclusion Sustainability of Stat3activation may plays an important control during the change of esophageal squmous cell carcinoma.

关 键 词：食管肿瘤/病理学 癌 鳞状细胞/病理学 信号传导 转录因子 人类 

分 类 号：R735.1[医药卫生—肿瘤]