生化阿司匹林抵抗与脑梗死的关系  

The study on the relationship between biochemical aspirin resistance and cerebral infarction

作　　者：石少亭[1] 李亚军[1] 张蓓[1] 王敏娟[1] 郭长江[1] 白婧[1] 

机构地区：[1]陕西省西安医学院附属医院神经内科,西安710077

出　　处：《中国神经精神疾病杂志》2010年第9期540-542,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：西安医学院附属医院院基金(编号:XYFY2007-06);西安医学院重点学科建设专项资金资助项目(编号:2009-02)

摘　　要：目的分析脑梗死患者中生化阿司匹林抵抗的发生率,探讨其与脑梗死以及与其他危险因素的关系。方法 75例脑梗死患者以及46例对照组人群,均服用阿司匹林100mg,1次/d。10d后采用比浊法以及尿11-脱氢-血栓素B2的检测,确定阿司匹林抵抗的发生率。结果阿司匹林抵抗者共7例,均出现于脑梗死组,对照组未见。阿司匹林半抵抗者病例组22例,对照组6例,两组间比较有统计学差异(P<0.05)。相对而言,女性中阿司匹林抵抗者更多见。结论阿司匹林抵抗是脑梗死的一个危险因素,而且在女性中更常见。如果脑梗死患者存在阿司匹林抵抗,应该改换其他药物治疗及预防脑梗死。Objective To estimate the frequency of biochemical aspirin resistance in patient with cerebral infarction and investigate the association of aspirin resistance with cerebral infarction and other stroke risk factors.Methods Seventy-five cerebral infarction patients and 46 control group cases received 100 mg/d of aspirin for 10 days.Aspirin resistance was detected using platelet aggregation test with turbidimetry and urinary 11-dehydro-Thromboxane B2.Results The case with aspirin resistance is 7 in patient group,and 0 in control group whereas the case with aspirin semi-responders is 22 in patient group and 6 in control group.Aspirin resistance and aspirin semi-responders was higher in patient group than in control group （P0.05）.Additionally,aspirin resistance was more common in female.Conclusions aspirin resistance is a risk factor for cerebral infarction and more common in female.We should use other platelet aggregation inhibitor to prevent cerebral infarction in stroke patients with aspirin resistance.

关 键 词：阿司匹林抵抗 脑梗死 血小板聚集 

分 类 号：R743.33[医药卫生—神经病学与精神病学]