激活吻侧无颗粒岛叶皮层内5-HT1A受体抑制福尔马林诱发的伤害性行为  

Activation of 5-HT_(1A) receptor in the rostral agranular insular cortex depressed the formalin-evoked nociceptive behavior in the rat

作　　者：霍福权[1] 吕伯昌[2] 张婷[2] 李云庆[2] 唐敬师[1] 

机构地区：[1]西安交通大学医学院生理学与病理生理学系,西安710061 [2]第四军医大学人体解剖与组织胚胎学教研室暨梁鲸琚脑研究中心,西安710032

出　　处：《神经解剖学杂志》2010年第5期470-474,共5页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金(30800334,30700222)

摘　　要：目的:明确5-HT1A受体是否参与吻侧无颗粒岛叶皮层(rostral agranular insular cortex,RAIC)介导的抗炎性持续性痛效应。方法:采用行为药理学实验方法观察RAIC内微量注射选择性5-HT1A受体激动剂和拮抗剂对福尔马林诱发的伤害性行为(缩足反应)的影响。结果:RAIC内微量注射选择性5-HT1A受体的激动剂8-OH-DPAT(5.0μg/0.5μl)明显抑制福尔马林诱发的大鼠缩足反应;向RAIC内提前5min预先微量注射5-HT1A受体拮抗剂NAN-190(10μg/0.5μl)则可拮抗8-OH-DPAT(5.0μg/0.5μl)对缩足反应的抑制效应;RAIC内单独注射NAN-190对福尔马林诱发的大鼠缩足反应没有影响。结论:5-HT1A受体参与RAIC介导的抗炎性持续性痛效应。Objective：To investigate whether 5-hydroxytryptamine 1A（5-HT1A）receptor in the rostral agranular insular cortex（RAIC）are involved in mediating the descending anti-persistent inflammatory nociceptive effects.Methods：The effects of microinjection of the selective 5-HT1A receptor agonist and antagonist on the formalin-evoked nociceptive behavior（flinching response）using animal behavior pharmacological method.Results：Microinjection of the selective 5-HT1A receptor agonist 8-OH-DPAT（5.0 μg/0.5 μl）into the RAIC depressed the formalin-evoked flinching responses,which was antagonized by pre-treatment with the selective 5-HT1A receptor antagonist NAN-190（10 μg/0.5 μl）in the same RAIC site.Microinjection of NAN-190 alone into the RAIC has no influence on the formalin-evoked flinching responses.Conclusion：These results suggest that 5-HT1A receptor in the RAIC are involved in mediating the descending antinociceptive effects on the persistent inflammatory nociception.

关 键 词：5-HT1A受体 福尔马林实验 缩足反应 吻侧无颗粒岛叶皮层 大鼠 

分 类 号：R363[医药卫生—病理学]