小清蛋白在孤独症模型大鼠上丘中表达的年龄变化(英文)  

Age-related changes of parvalbumin expression in superior colliculus of prenatal valproate exposure rats

作　　者：徐理[1] 王中平[1] 孙燕[1] 彭裕文[1] 李瑞锡[1,2] 

机构地区：[1]复旦大学上海医学院人体解剖与组织胚胎学系,上海200032 [2]复旦大学脑科学研究院,上海200032

出　　处：《神经解剖学杂志》2010年第5期491-496,共6页Chinese Journal of Neuroanatomy

基　　金：supported by the public fund from institute of brain science,Fudan University(2007),the basic-clinical joining research grant of Shanghai Medical College,Fudan University(2007-09);the doctorate fund of Ministry of Education(No.070246184)~~

摘　　要：目的:研究小清蛋白(PV)在孤独症模型大鼠上丘的表达变化。方法:用免疫组织化学及Western Blot技术,检测了胚胎期丙戊酸受药大鼠孤独症模型发育过程中上丘内PV阳性神经元的数目和PV蛋白的表达。结果:孤独症模型大鼠上丘PV阳性神经元的数目在幼年期(生后20d)明显增多,而在成年时期减少;PV蛋白的表达也相应地在幼年期增多,成年期降低(生后90d,P<0.05)。结论:上丘内PV的表达随发育阶段而呈现的先增高后降低的表达变化,可能与孤独症特有的眼扫视异常有关。Objective：To investigate the expression of parvalbumin（PV）in superior colliculus（SC）of an autism model of rat.Methods：The immunohistochemical and Western blot methods were used to investigate the numbers of PV-immunoreactive（IR）neurons and the expression of PV protein in SC of an autism animal model induced by prenatal valproate exposure.Results：The numbers of the PV-IR neurons and the expression of PV protein in SC were increased in the young rat（postnatal day 20）and decreased at adult（postnatal day 90）（P〈0.05）in autism model group compared to the control group.Conclusion：The age-related abnormality of PV expression in SC,which was increased in juvenile then decreased in adult,might associate with peculiar saccade pattern in autism individuals.

关 键 词：小清蛋白 丙戊酸 上丘 孤独症 动物模型 大鼠 

分 类 号：R749.94[医药卫生—神经病学与精神病学]