Features of the PHF8/KIAA1718 histone demethylase  

作　　者：Tamaki Suganuma Jerry L Workman 

机构地区：[1]Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA

出　　处：《Cell Research》2010年第8期861-862,共2页细胞研究（英文版）

摘　　要：Gene regulation mechanisms in cellular events ranging from development to tumorigenesis target the fundamental unit of chromatin structure, the nucleosome, 146 bp of DNA wrapped around a histone octamer. Covalent modifications of histories play key roles in the function of the genome. Histones are methylated on lysine （K） and arginine （R） residues. Methylation has been shown to occur on five K residues of histone H3 （K4, K9, K27, K36 and K79）,

关 键 词：组蛋白H3 甲基化酶 染色质结构 活动范围 调控机制 基本单位 共价修饰 基因组 

分 类 号：Q783.1[生物学—分子生物学] S511[农业科学—作物学]