进展期胃癌术后多西他赛联合卡培他宾化疗及同步放疗的临床研究  

Docetaxel plus capecitabine in concomitant radiotherapy for advanced gastric carcinoma postoperation

作　　者：郭红伟 靳秀丽 魏桂芳 刘卓林 

机构地区：[1]长治市第二人民医院普外科,山西长治046000

出　　处：《中国癌症杂志》2010年第9期699-702,共4页China Oncology

摘　　要：背景与目的:进展期胃癌根治术后患者往往容易复发,因此临床上防止该术式术后肿瘤复发是一个棘手的问题。基于此原因,本文旨在评价进展期胃癌根治术后予以多西他赛联合卡培他宾化疗及同步放疗的疗效及治疗耐受性。方法:85例进展期胃癌根治术后患者随机分为2组,同步放化疗组(试验组)44例,采用多西他赛(TXT)+卡培他宾方案化疗并同步放疗;单纯化疗组(对照组)41例,采用多西他赛+奥沙利铂(L-OHP)+5-氟尿嘧啶(5-FU)/醛氢叶酸(CF)化疗方案,比较两组的治疗不良反应发生率及1年3年生存率。结果:试验组1年及3年生存率分别为84.1%(37/44)、65.9%(29/44),对照组分别为61.0%(25/41)、39.0%(16/41),两组1年及3年生存率比较差异均有统计学意义(P=0.017,P=0.013)。试验组不良反应发生率77.3%(34/44)而对照组为61.0%(25/41),两组间不良反应发生率差异无统计学意义(P=0.103)。结论:进展期胃癌根治术后采用多西他赛联合卡培他宾化疗并同步放疗与术后单纯化疗相比能显著提高患者的1、3年生存率,且患者容易耐受。Background and purpose：Patients with advanced gastric cancer often easily relapse after surgery.Therefore preventing the progress of clinical recurrence after the radical resection of gastric cancer is a diffi cult problem.The purpose of this study was to evaluate the effi cacy and side effects of docetaxel plus capecitabine in concomitant radiochemotherapy for patients with advanced gastric carcinoma postoperation.Methods：Eightyfive patients with advanced gastric carcinoma after radical gastrectomy were randomly divided into two groups：synchronization radiochemotherapy group （test group）,who received docetaxel ＋ capecitabine regimen chemotherapy and concomitant radiotherapy （44 cases） and the chemotherapy alone group （control group）,who received docetaxel ＋ L-OHP ＋ 5-FU/CF regimen chemotherapy （41 cases）.The side effects as well as the 1-and 3-year survival rates were compared between the two groups.Results：One-and 3-year survival rates were 84.1% and 65.9% in test group and 61.0% and 39.0% in the control group,respectively,there was a signifi cant difference （P=0.017,P=0.013 for 3-year）.The side effect in the test group was 77.3% and 61.0% in the control group （P=0.103）.Conclusion：Postoperative chemotherapy in concomitant with radiotherapy is effective,in comparison with chemotherapy alone,could improve the 1-and 3-year survival rates in advanced gastric carcinoma patients.The side effects of radiochemotherapy are tolerable.

关 键 词：胃癌 化疗 放疗 多西他赛 卡培他宾 

分 类 号：R735.2[医药卫生—肿瘤]