Brain gliomas Biological characteristics and correlation with the status of adjacent corticospinal tracts  

作　　者：Chaoshi Niu Xiaorui Fei Changxin Wang Jiaming Mei Ying Liu Min Ding 

机构地区：[1]Department of Neurosurgery,Anhui Provincial Hospital,Anhui Medical University,Hefei 230001,Anhui Province,China [2]Molecular Neurobiology & Neural Regeneration and Repairing Laboratory,Anhui Provincial Stereotactic Neurosurgical Institute,Hefei 230001,Anhui Provine,China [3]Department of Radiology,Anhui Provincial Hospital Anhui Medical University,Hefei 230001,Anhui Province,China [4]Department of Pathology,Anhui Provincial Hospital,Anhui Medical University,Hefei 230001,Anhui Province,China

出　　处：《Neural Regeneration Research》2010年第17期1347-1352,共6页中国神经再生研究（英文版）

基　　金：Anhui Prov-ince Grant of Tackle Key Problems in Science and Technology, No. 07010302202

摘　　要：Malignant behaviors of brain gliomas include proliferation and infiltration.It remains unclear which behavior influences the status of adjacent corticospinal tracts.Diffusion tensor imaging can show the status of brain white matter fiber tracts.Ki-67 and CD44/matrix metalloproteinase 9 are sensitive markers for reflecting the proliferation and infiltration of tumor cells.The present study analyzed pre-operative diffusion tensor images of 24 patients with pathologically confirmed World Health Organization glioma（Ⅰ-Ⅳ）.We observed lapse,infiltration and destruction of the peri-tumor corticospinal tract following reconstruction,and simultaneously detected the expression of Ki-67,CD44/matrix metalloproteinase 9 in samples.Expression of CD44 and matrix metalloproteinase 9was not significantly correlated to the status of the peri-tumor corticospinal tract（r = 1.597,4.859;P = 0.450,0.088）,while Ki-67 expression significantly correlated to its status（r= 6.590,P = 0.037）.These findings demonstrate that highly proliferative gliomas result in damage to the peripheral corticospinal tract.Malignant behaviors of brain gliomas include proliferation and infiltration.It remains unclear which behavior influences the status of adjacent corticospinal tracts.Diffusion tensor imaging can show the status of brain white matter fiber tracts.Ki-67 and CD44/matrix metalloproteinase 9 are sensitive markers for reflecting the proliferation and infiltration of tumor cells.The present study analyzed pre-operative diffusion tensor images of 24 patients with pathologically confirmed World Health Organization glioma（Ⅰ-Ⅳ）.We observed lapse,infiltration and destruction of the peri-tumor corticospinal tract following reconstruction,and simultaneously detected the expression of Ki-67,CD44/matrix metalloproteinase 9 in samples.Expression of CD44 and matrix metalloproteinase 9was not significantly correlated to the status of the peri-tumor corticospinal tract（r = 1.597,4.859;P = 0.450,0.088）,while Ki-67 expression significantly correlated to its status（r= 6.590,P = 0.037）.These findings demonstrate that highly proliferative gliomas result in damage to the peripheral corticospinal tract.

关 键 词：brain gliomas corticospinal tracts diffusion tensor imaging fiber tract PATHOLOGY BIOLOGY 

分 类 号：Q959.804[生物学—动物学] TH774[机械工程—仪器科学与技术]