Y14在乳腺癌组织中的表达及意义  

Expression of Y14 in Human Breast Cancer Tissue and Its Significance

作　　者：孔令泉[1] 蒲莹晖[2] 任国胜[1] 

机构地区：[1]重庆医科大学附属第一医院普外科,重庆市400016 [2]重庆工商大学外语学院

出　　处：《中国肿瘤临床》2010年第19期1106-1108,1114,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金(编号:NSTC;30571822);重庆市自然科学基金计划项目基金资助(编号:CSTC;2006BA5004)

摘　　要：目的:研究Y14在乳腺癌组织、乳腺良性肿瘤组织及癌旁乳腺组织的表达及意义。方法:应用westem blotting、RT-PCR等方法测定Y14在乳腺癌组织、乳腺良性肿瘤组织及癌旁乳腺组织的表达情况。结果:1)Y14在乳腺癌组织和癌旁乳腺组织的表达水平有明显差异,乳腺癌组织的Y14表达明显高于癌旁乳腺组织(P<0.05)。2)在乳腺癌中,组织学Ⅲ级组的Y14表达明显高于Ⅰ级和Ⅱ级组(P<0.05)。3)有淋巴结转移的腋窝淋巴结(+)组的Y14表达高于腋窝淋巴结(-)组(P<0.05)。4)乳腺癌≤2cm组的Y14和upf1表达和>2cm组的差异无统计学意义(P>0.05)。结论:Y14的作用在乳腺癌组织中明显增强。Y14的表达在组织学Ⅲ级和腋窝淋巴结转移(+)乳腺癌组织中表达增高,与肿瘤大小无关。Objective： TO study the expression of Y14 in human breast cancer and its significance. Methods： Western blot and RT-PCR were applied to detect the expression of Y14 in human breast cancer tissue and tumor-adjacent tissue. Results： Y14 expression was higher in human breast cancer tissue than in tumor-adjacent tissue （P〈0.05）. Y14 expression was higher in pathological grade In tissue than in grade [ and 11 tissue （P〈0.05）. Y14 expression in breast cancer tissue from patients with positive axillary lymph nodes was higher than in breast cancer tissue from patients without positive axil- lary lymph nodes （P〈0.05）. No significant difference was found in Y14 expression between breast cancer tissue from pa- tients with a tumor smaller than 2 cm in diameter and breast cancer tissue fi＇om patients with a tumor larger than 2 cm in di- ameter （P〈0.05）. Conclusion： Y14 expression is increased in breast cancer tissue. Y14 expression is increased in pathological grade Ⅲ tissue and tissue from patients with positive axillary lymph nodesl There is no correlation between Y14 expression and tumor size.

关 键 词：人乳腺癌组织 癌旁乳腺组织 WESTERN BLOT RT-PCR 

分 类 号：R737.9[医药卫生—肿瘤]