B细胞非霍奇金淋巴瘤肿瘤组织CD22抗原表达检测及临床意义  

CD22 Expression in B Cell Non-Hodgkin's Lymphoma Tissues and Its Clinical Significance

作　　者：张东生[1] 丁娅[2] 李苏[1] 黄慧强[1] 夏忠军[1] 李志铭[1] 林旭滨[1] 姜文奇[1] 

机构地区：[1]华南肿瘤学国家重点实验室∥中山大学肿瘤防治中心内科,广东广州510060 [2]华南肿瘤学国家重点实验室∥中山大学肿瘤防治中心生物治疗中心,广东广州510060

出　　处：《中山大学学报（医学科学版）》2010年第5期706-709,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：卫生部重大新药创制科技重大专项(2008ZX09312-002)

摘　　要：【目的】检测CD22抗原在非霍奇金淋巴瘤肿瘤组织中的表达,初步探讨CD22抗原在非霍奇金淋巴瘤肿瘤组织的表达和临床病理特征的关系。【方法】采用免疫组化方法检测B细胞非霍奇金淋巴瘤肿瘤组织CD22抗原的表达,分析肿瘤组织CD22抗原表达和临床病理特征等的关系。【结果】CD22抗原在B细胞非霍奇金淋巴瘤肿瘤组织阳性表达主要见于细胞浆和细胞膜。全组21例,阳性率100.00%(21/21),强阳性(+++)率14.29%(3/21),中等阳性(++)率33.33%(7/21),弱阳性率(+)52.38%(11/21)。CD22表达与病理亚型、性别、年龄以及其它临床病理特征等无明显相关性。【结论】CD22抗原在B细胞非霍奇金淋巴瘤中广泛表达,可以采用免疫组化的方法检测出,该方法简单易行,有一定临床应用前景;B细胞非霍奇金淋巴瘤组织CD22表达和临床病理特征的关系需进一步研究。Objective To examine the CD22 antigen expression in B cell non-Hodgkin＇s lymphoma（NHL） tissues and investigate its relationship with clinicopathological characteristics.Methods CD22 antigen expression in B cell NHL tissues was detected with immunohistochemistry staining.The correlation between CD22 expression and clinicopathological characteristics was analyzed.Results CD22 antigen was detected in B cell NHL tissue section by immunohistochemistry staining.The positive staining particles were located in cytoplasma and/or membrane.CD22 expression was showed in the total 21 cases（positive rate 100.00%）.Strong expression in 3 cases（14.29%）,moderate expression in 7 cases（33.33%）,and weak expression was detected in 11 cases（52.38%）.CD22 expression in B cell NHL tissue was not correlated with pathologic subtypes,gender,age,or other clinicopathological characteristics.Conclusion CD22 antigen is generally expressed in B cell NHL and easily detected by immunohistochemistry staining,and the detection method can be used in clinical practice.CD22 expression in B cell NHL tissue and its relationship with clinicopathological characteristics needs further study.

关 键 词：非霍奇金淋巴瘤 CD22抗原 免疫组化 

分 类 号：R733.1[医药卫生—肿瘤]