中国人群ALOX5AP基因SG13S114A/T多态性与缺血性卒中相关性的Meta分析  

A Meta analysis on the association of ALOX5AP gene SG13S114A/T polymorphism with ischemic stroke in Chinese population

作　　者：徐佳亮[1] 蔺慕会[1] 陈晓虹[1] 何志义[2] 白璇[1] 吕姣[1] 

机构地区：[1]辽宁省人民医院神经内六科,辽宁沈阳110001 [2]中国医科大学第一医院神经内科,辽宁沈阳110001

出　　处：《中风与神经疾病杂志》2010年第9期811-814,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的对5-脂氧合酶激活蛋白(ALOX5AP)基因第1内含子SG13S114A/T多态性与缺血性卒中(IS)的关联性研究进行meta分析。方法通过文献检索2004～2009年发表的中国人ALOX5AP基因SG13S114A/T多态性与IS相关性的病例-对照研究,剔除不符合要求的文献;以基因型和等位基因频数的优势比(OR)值为统计量,以漏斗图和Egger法检验发表偏倚,根据同质性检验结果合并数据,采用Revman4.2版统计软件进行数据统计。结果 5篇文献符合条件纳入研究,入选文献无明显发表偏倚。同质性检验显示基因型(AA+AT)/TT的统计量χ2=1.00,P=0.91;等位基因频数A/T的统计量χ2=8.18,P=0.09,各研究间无异质性。数据合并结果显示,SG13S114A/T位点(AA+AT)/TT的OR值为1.22,95%CI为1.09～1.36,Z值为3.5,P<0.05;等位基因频数A/T的OR值为1.05,95%CI为0.96～1.14,Z值为1.09,P=0.28。结论 ALOX5AP基因SG13S114A/T多态性与中国人群IS具有相关性,AA基因型可能是IS的易感基因型。Objective To study a Meta analysis on the association 5-lipoxygenase activating protein（ALOX5AP）gene first intron SG13S114A/T polymorphism with ischemic stroke（IS）in Chinese population.Methods The case-control studies of the association between ALOX5AP gene SG13S114A/T polymorphism and IS were searched.The studies were published in Chinese from 2004 to 2009.The available literatures were reviewed.The odds ratio（OR）of genotype and allele frequencies was regarded as statistics value,and publication bias was determined by funnel plot and Egger＇s protocol.The data was pooled according to the results of homogeneity test with RevMan 4.2 software.Results Five literatures met the criterion and were included in the Meta study,and significant publication bias was showed.Homogeneity test results showed genotype（AA＋AT）/TT staticstica χ2=1.00,P=0.91,allele frequencies A/T staticstica χ2=8.18,P=0.09.Pooled data results showed the OR value of（AA＋AT）/TT was 1.22（95%CI为1.09～1.36）,Z=3.5 with P〈0.05,and the allele frequencies OR value of A/T was 1.05（95%CI为0.96～1.14）,Z=1.09 with P=0.28.Conclusion ALOX5AP gene SG13S114A/T polymorphism relates with Chinese population IS,and AA genotype may be susceptible genotype of IS.

关 键 词：5-脂氧合酶激活蛋白基因 多态性 缺血性卒中 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]