头孢菌素C发酵液可压缩性及膜分离工艺研究  

Research on the compressibility of cephalosporin C fermentation broth

作　　者：鲍建芝[1] 李杰[1] 卢华[1] 陈尧[1] 周天舒[1] 张立平[1] 韩培胜[1] 张晓艳[1] 

机构地区：[1]石药集团,石家庄050041

出　　处：《膜科学与技术》2010年第5期77-79,共3页Membrane Science and Technology

基　　金：<抗生素大规模生产关键技术创新>(国家科技支撑配套项目(07276447D))

摘　　要：研究头孢菌素C发酵液,确定头C发酵液具有一定的可压缩性,可压缩性指数在0.30-0.45之间.提出有效透膜压差的概念,认为膜通量与有效透膜压差成正比,对膜通量分析有积极作用.进一步探讨发酵液可压缩性对膜分离的影响,得出结论：可压缩性指数越小,有效透膜压差和透过通量越大,越有利于膜分离过程.Based on the study of cephalosporin C broth,it was confirmed that cephalosporin C broth was compressible and the value of the compressibility of its cake ranged from 0.30~0.45.A new concept of the effectual pressure drop of transferring membrane（ΔPe） was presented and the flux was proportional to ΔPe.After studyed the effect of the compressibility on membrane separation,it can be concluded that the decreases of the compressibility and viscosity are favourable to ΔPeand flux.

关 键 词：头孢菌素C 发酵液 可压缩性 通量 

分 类 号：TQ465[化学工程—制药化工]