灌肠方治疗溃疡性结肠炎的临床疗效及对血清D-二聚体和血小板参数的影响  

Therapeutic Effects of Guanchangfang on Ulcerative Colitis and Changes of D-D PLT and MPV in Sera

作　　者：胡连海[1] 肖成[1] 李国栋[1] 宋晓娜[2] 陈秀杉[2] 

机构地区：[1]中国中医科学院广安门医院肛肠科,北京100053 [2]山东大学齐鲁医院,山东济南250012

出　　处：《辽宁中医杂志》2010年第10期1958-1959,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察灌肠方对溃疡性结肠炎(UC)患者的临床疗效及对血清D-D、PLT和MPV的影响。方法:收集40例UC患者,随机分为灌肠方治疗组(20例)和柳氮磺胺吡啶对照组(20例)。治疗3周后,观察临床症状以及治疗前后血清D-D、PLT和MPV水平的变化。结果:治疗组临床症状改善优于对照组。治疗组患者血清D-D和PLT水平降低、MPV水平升高较对照组显著(P<0.05)。结论:灌肠方治疗UC疗效显著;降低血清D-D和PLT水平以及升高MPV水平可能是其治疗UC的机制之一。Objective：To observe the therapeutic effects of Guanchangfang and its effect on the serum levels of D-D,PLT and MPV in patients with ulcerative colitis（UC）.Methods：A total of 40 UC patients were randomly classified into Guanchangfang-treated group（n=20）and sulfasalazine-treated group（n =20）.Clinical symptoms,D-D,PLT and MPV levels in sera were evaluated 3 weeks after treatment.Results：Compared with those of sulfasalazine-treated group,colonic mucosal inflammation in Guanchangfang-treated group was significantly improved（P0.05）,and serum levels of D-D,PLT and MPV markedly changed（P0.05）.Conclusion：Guanchangfang is effective to treat ulcerative colitis and can lower the serum content of D-D and PLT,and can increase MPV in sera,which may be an important pathway in clinical trail.

关 键 词：灌肠方 柳氮磺胺吡啶 溃疡性结肠炎 D-二聚体 血小板计数 血小板平均体积 

分 类 号：R574.62[医药卫生—消化系统]