基于功能磁共振成像的早发精神分裂症默认网络研究  

Default mode network analysis in early onset schizophrenia using functional magnetic resonance imaging

作　　者：唐劲松[1] 陈晓岗[1] 周炳[2] 廖艳辉[1] 刘卫青[1] 谭长连[2] 王秀艳[1] 王栋[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]中南大学湘雅二医院放射科

出　　处：《临床精神医学杂志》2010年第5期289-292,共4页Journal of Clinical Psychiatry

基　　金：国家自然科学基金(30870893;30900486);973课题(2006CB500808;2007CB512301)

摘　　要：目的:探讨早发精神分裂患者在静息状态下脑默认网络功能连接特点。方法:采用功能磁共振成像(fMRI)技术,对26例早发精神分裂症患者和28例正常对照进行静息状态下全脑的磁共振脑功能扫描。采用功能连接分析方法,提取静息状态下默认网络,在患者组和对照组中分别计算默认网络各脑区两两间的功能连接。结果:早发精神分裂症组在默认网络存在5条异常连接。其中3条连接表现为连接增强:腹侧前额叶内侧皮质-右侧颞下回(P=0.0078),腹侧前额叶内侧皮质-左侧外侧顶叶(P=0.0091)、腹侧前额叶内侧皮质-背侧前额叶内侧皮质(P=0.0163)。2条连接表现为连接减弱:右侧外侧顶叶-小脑扁桃体(P=0.0223),左侧额上回-右侧下半月小叶(P=0.0294)。结论:早发精神分裂症患者存在默认网络功能的异常。这些异常改变可能与精神分裂症的病理机制相关。Objective：To explore the brain default mode network function connection in early onset schizophrenia using functional magnetic resonance imaging. Method：Twenty six adolescents with early-onset schizophrenia and 28 healthy volunteers were tested in a resting-state fMRI scan. Functional connectivity analy-sis was used to reconstruct the default network in patients and healthy volunteers. Results：Five significantly abnormal connections were found in the patients group. Three increased connections were the connections between：ventral medialprefrontal cortex （ MPFC） and right inferior temporal gyrus （ P = 0. 0078） ,ventral MPFC and left angular gyrus （ P = 0. 0091） ,ventral MPFC and dorsal MPFC （ P = 0. 0163）. Two decreased connections were the connections between：right angular gyrus and right inferior semi-lunar lobule （ P = 0. 0223） ,left superior frontal gyrus and cerebellar tonsil（ P = 0. 0294）. Conclusion：Within the default network,the major abnormal connections are correlated to MPFC. The abnormalities could be the source of the abnormal of introspectively oriented mental actives.

关 键 词：早发精神分裂症 磁共振成像 静息状态 默认网络 功能连接 

分 类 号：R749.3[医药卫生—神经病学与精神病学]