儿童精神分裂症注意功能缺陷与儿茶酚氧位甲基转移酶基因多态性  

Attention function and correlates of the catechol-O-methyl transferase polymorphism in children with schizophrenia

作　　者：卢建平[1] 吴怀安[1] 舒明跃[1] 杨志伟[1] 张旋[1] 邓小敏[1] 

机构地区：[1]深圳市康宁医院,广东518029

出　　处：《临床精神医学杂志》2010年第5期297-299,共3页Journal of Clinical Psychiatry

基　　金：广东省医学科研基金资助(A2007583)

摘　　要：目的:探讨儿童首发精神分裂症及其神经认知功能损害与儿茶酚氧位甲基转移酶(COMT)基因多态性的相关性。方法:应用聚合酶链反应和限制性片段长度多态性技术,检测77例儿童首发精神分裂症患者(简称患者组)和90名正常人(简称对照组)的COMT基因型,采用整合视听连续执行测验(IVA)评估25例儿童首发精神分裂症患者的注意功能、反应控制能力;比较分析儿童首发精神分裂症及其注意功能与COMT基因多态性的相关性。结果:两组COMT基因多态性的基因型频率差异无显著性(χ2=5.042,P=0.080),患者组的COMT基因的高活性等位基因缬氨酸(VAL)频率高于对照组,但差异无显著性(χ2=0.756,P=0.385);注意障碍组和非注意障碍组的COMT基因型频率分布两组之间的差异无显著性(χ2=0.818,P=0.366),注意障碍组和非注意障碍组的COMT基因的等位基因频率分布两组之间的差异无显著性(χ2=0.063,P=0.802)。结论:COMT基因可能不是儿童精神分裂症的易感基因,儿童精神分裂症注意功能缺陷与COMT基因可能不存在显著相关性。Objective：To study the attention function and correlates of the catechol-O-methyl transferase （ COMT） polymorphism in child patients with schizophrenia. Method：Seventy seven patients with child schizophrenia,90 normal controls were included in the study. The COMT gene polymorphisms were determined with the polymerase chain reaction and restriction fragment length polymorphism technique. Attention function were measured with integrated visual and auditory continuous performance test （ IVA）. Results：The frequen-cies of COMT genotype were not significantly different between the patients and normal controls（ χ2 = 5. 042,P = 0. 080）. The frequencies of COMT genotypic distribution between attention function deficiency group and non-attention function deficiency group were not statistical significantly different （ χ2 = 0. 063,P = 0. 802）. Conclusion：There might not be a susceptibility gene to child schizophrenia on chromosome 22; COMT gene may not play a role in attention function of child schizophrenia.

关 键 词：儿童精神分裂症 遗传 注意 儿茶酚氧位甲基转移酶 多态性 

分 类 号：R749.94[医药卫生—神经病学与精神病学]