奥氮平对老年抑郁症的增效作用  

A study of paroxetine combined with olanzapine in the treatment of geriatric depression

作　　者：王东明[1] 刘琳琳[1] 景艳玲[1] 刘锡亮[1] 孙祥虹[1] 曲春晖[1] 

机构地区：[1]山东青岛市精神卫生中心,266034

出　　处：《临床精神医学杂志》2010年第5期342-343,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨帕罗西汀联合小剂量奥氮平治疗老年抑郁症的疗效和安全性。方法:将96例老年抑郁症患者随机分为研究组和对照组,研究组采用帕罗西汀合并奥氮平治疗,对照组用帕罗西汀治疗,治疗12周。两组分别在治疗2、4、8、12周,采用汉密尔顿抑郁量表(HAMD)、临床疗效总评量表(CGI)评定疗效,用治疗中出现的症状量表(TESS)评定不良反应。结果:研究组HAMD评分降分率显著较大,CGI评分显著较低,两组TESS评分相仿。结论:帕罗西汀联合小剂量奥氮平治疗老年抑郁症的疗效好,不良反应无明显增加。Objective：To explore the efficacy and side effects of paroxetine combined with small dose olanzapine in treatment of geriatric depression. Method：96 elderly patients were randomly assigned to study group （ n = 48） and control group （ n = 48） for 12 weeks. The study group was treated with paroxetine combined with olanzapine while control group with paroxetine only. The clinical efficacy was evaluated using Hamilton depression scale （ HAMD） as well as clinical global impression （ CGI） ,and the side effects were evaluated by treatment emergent symptom scale （ TESS） after 2、4、8、12 weeks treatment. Results：The study group showed more decreases in HAMD and CGI score than control group. There were no significant differences in TESS reduction. Conclusion：Paroxetine combined with small dose olanzapine is effective in the treatment of geriatric depression with fewer side effects.

关 键 词：老年抑郁症 帕罗西汀 奥氮平 

分 类 号：R749.4[医药卫生—神经病学与精神病学]