晚期非小细胞肺癌血浆纤维蛋白原、D-二聚体及血小板水平与预后的相关性研究  

Correlative study on plasma levels of fibrinogen,D-dimer,platelet count and prognosis in patients with advanced non-small lung cancer

作　　者：郜靓[1] 张亚雷[1] 杨海虹[2] 

机构地区：[1]广州医学院第一附属医院肿瘤血液中心,广东广州510230 [2]广州医学院第一附属医院呼吸疾病研究所,广东广州510230

出　　处：《安徽医药》2010年第11期1311-1312,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨晚期非小细胞肺癌患者血浆纤维蛋白原、D-二聚体水平及血小板计数与其预后的相关性。方法测定112例晚期非小细胞肺癌患者(肺癌组)及30例健康体检者(对照组)血浆纤维蛋白原、D-二聚体水平及血小板计数并进行对比分析。结果肺癌组血浆纤维蛋白原、D-二聚体水平及血小板计数高于对照组(P<0.05),肺癌组血浆纤维蛋白原、D-二聚体水平及血小板计数与病理类型、肿瘤大小、TNM分期之间无明显关系。晚期非小细胞肺癌患者血浆纤维蛋白原、D-二聚体水平及血小板计数与生存期呈显著负相关。结论晚期非小细胞肺癌患者血液处于高凝状态,血浆纤维蛋白原、D-二聚体水平及血小板计数与患者的预后密切相关。抗凝治疗对控制晚期非小细胞肺癌患者病情的发展及预后可能有重要的临床意义。Aim To explore the relationship among plasma levels of fibrinogen,D-dimer,platelet count and the prognosis in patients with advanced non-small lung cancer.Methods The plasma levels of fibrinogen,D-dimer and platelet count were detected in 112 patients with advanced non-small lung cancer and 30 normal controls.Results The D-dimer,plasma fibrinogen and platelet count were significantly higher than those of normal controls（P〈0.05）.The plasma levels of fibrinogen,D-dimer and platelet count in patients with advanced non-small lung cancer were not related to histological classification,the size of the primary tumors or TNM stages,and were negatively correlated to the survival.Conclusion The hypercoagulability state exists in the patients with advanced non-small lung cancer.The plasma levels of fibrinogen,D-dimer and platelet count in the patients with advanced non-small lung cancer are correlated with the prognosis.The anti-coagulability treatment may play an important role in controlling the development and prognosis of advanced non-small lung cancer.

关 键 词：非小细胞肺癌 纤维蛋白原 D-二聚体 血小板计数 预后 

分 类 号：R734.2[医药卫生—肿瘤]