Preparation and Photodynamic Anti-tumor Activity of Magnetic Polylactic Acid Nanoparticles Loaded with Photosensitizer  

作　　者：杨晓霞 黄慧 陈志龙 黄鹏 孙筠 周兴平 

机构地区：[1]Key Laboratory of Textile Science & Technology,Ministry of Education,Donghua University [2]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University

出　　处：《Journal of Donghua University(English Edition)》2010年第3期306-311,共6页东华大学学报（英文版）

基　　金：National Natural Science Foundations of China(No.30070862,No.30271534);Shanghai Municipal Natural Science Foundation,China(No.05ZR14002,No.06PJ14001,No.064319020,No.108146);the FundamentalResearch Funds for the Central Universities,China(No.10D10514)

摘　　要：A novel magnetic nanocarrier was strategically designed and successfully prepared.Photosensitizer 2,7,12,18-tetramethyl-3,8-di-(1-propoxyethyl)-13,17-bis-(3-hydroxypropyl)porphyrin(PHPP)was encapsulated into polylactic acid(PLA)-coated Fe3O4 nanoparticles.The diameter of nanocarrier is 30-50 nm by transmission electron micrograph(TEM).The encapsulation efficiency of photosensitizer is 27.98% calculated from UV-vis absorption spectra.The nanocarrier shows obvious photocytotoxic activity to Hela299 tumor cells in vitro.A novel magnetic nanocarrier was strategically designed and successfully prepared.Photosensitizer 2,7,12,18-tetramethyl-3,8-di-（1-propoxyethyl）-13,17-bis-（3-hydroxypropyl）porphyrin（PHPP）was encapsulated into polylactic acid（PLA）-coated Fe3O4 nanoparticles.The diameter of nanocarrier is 30-50 nm by transmission electron micrograph（TEM）.The encapsulation efficiency of photosensitizer is 27.98% calculated from UV-vis absorption spectra.The nanocarrier shows obvious photocytotoxic activity to Hela299 tumor cells in vitro.

关 键 词：photocytotoxic activity PHOTOSENSITIZER polylactic acid（PLA） magnetic nanocarriers TUMOR 

分 类 号：R318.51[医药卫生—生物医学工程]