Synthesis and Characterization of Magnetic SiO_2 Nanoparticles Loaded with Naproxen for Anti-inflammatory Therapy  

作　　者：杨晓霞 陈志龙 黄鹏 周兴平 

机构地区：[1]Key Laboratory of Textile Science & Technology of Eco-Textile,Ministry of Education,Donghua University [2]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University

出　　处：《Journal of Donghua University(English Edition)》2010年第3期364-369,共6页东华大学学报（英文版）

基　　金：National Natural Science Foundations of China(No.30070862,No.30271534);Shanghai Municipal Natural Science Foundation,China(No.05ZR14002,No.06PJ14001,No.064319020,No.108146);the Fundamental Research Funds for the Central Universities,China(No.10D10514)

摘　　要：The aim of this study is to synthesize of magnetic SiO2 nanoparticles(MSNPs)loaded with Naproxen(NAP-MSNPs)for targeting anti-flammatory therapy.The Fe3O4 nanoparticles were coated with a thin layer of silica by stber method and the drug was encapsulated in it simultaneously.The optimal conditions were investigated for the synthesis of MSNPs.The shape,size,and phase structure of NAP-MSNP were characterized by transmission electron micrographs(TEM)and X-ray diffraction(XRD).The drug encapsulation efficiency was confirmed by FT-IR and measured by UV spectrometry.The NAP-MSNPs show the response at the external magnetic field and the drug could be released readily from NAP-MSNPs.All of these facts suggest the NAP-MSNPs could be applied in a promising drug release-controlling system for targeting anti-inflammatory therapy.The aim of this study is to synthesize of magnetic SiO2 nanoparticles（MSNPs）loaded with Naproxen（NAP-MSNPs）for targeting anti-flammatory therapy.The Fe3O4 nanoparticles were coated with a thin layer of silica by stber method and the drug was encapsulated in it simultaneously.The optimal conditions were investigated for the synthesis of MSNPs.The shape,size,and phase structure of NAP-MSNP were characterized by transmission electron micrographs（TEM）and X-ray diffraction（XRD）.The drug encapsulation efficiency was confirmed by FT-IR and measured by UV spectrometry.The NAP-MSNPs show the response at the external magnetic field and the drug could be released readily from NAP-MSNPs.All of these facts suggest the NAP-MSNPs could be applied in a promising drug release-controlling system for targeting anti-inflammatory therapy.

关 键 词：MAGNETIC NAPROXEN NANOPARTICLE drug delivery FE3O4 

分 类 号：R318.51[医药卫生—生物医学工程]