鼻咽癌放疗后听力损失的多因素分析  

作　　者：刘伊辉[1] 张学成[1] 张启富[1] 

机构地区：[1]山东潍坊医学院附属医院放疗科,261031

出　　处：《当代医学》2010年第28期48-49,共2页Contemporary Medicine

摘　　要：目的研究放疗对鼻咽癌患者的听力损伤,分析影响听力的相关因素。方法用纯音电测听仪对患者放疗期间不同时间点的听力进行测试,采用Logistic回归方程对患者年龄、性别、肿瘤分期、化疗药物等进行多因素分析。结果鼻咽癌放疗后气导各频率听阈值随着放疗时间的推移呈上升趋势,放疗后感音神经性听力下降与患者性别、年龄及联合顺铂有关。结论鼻咽癌放疗后听力下降与患者的性别、年龄及应用顺铂的相关性有统计学意义。Objective To study the post–irradiation hearing loss in patients suffering from nasopharyngeal carcinoma, and analyze the contributory influences. Methods pure-tone audiometry evaluation were performed in all patients with NPC who received radiotherapy, the contributory influences such as age, sex, irradiative dose and the use of CDDP were evaluated. Results As time going by,the meall air-conduction threshold at different frequencies after radiotherapy gradually increased.The hearing loss was correlated with the patient’s age, sex and chemotherapy including CDDP. Conclusion The risk of the sensorineuml hearing loss was evidently correlated with the patient’s age, sex and chemotherapy including CDDP.

关 键 词：鼻咽癌 放疗 纯音听阈测试 顺铂 

分 类 号：R739.63[医药卫生—肿瘤]