HC2-HPV检测辅助液基细胞学对宫颈癌筛查的临床价值  

Clinical values of HC2-HPV detection and liquid based cytology in screening of cervical cancer

作　　者：许超[1] 周家德[2] 

机构地区：[1]安徽省合肥市妇幼保健院宫颈疾病中心,230001 [2]安徽医科大学第一附属医院妇产科

出　　处：《中国妇幼保健》2010年第30期4350-4352,共3页Maternal and Child Health Care of China

基　　金：2008年安徽省临床医学技术应用项目〔2008D01〕

摘　　要：目的:探讨二代杂交捕获技术联合薄层液基细胞学在宫颈癌筛查中的应用价值。方法:采用薄层液基细胞学技术进行细胞学检查,同时采用二代杂交捕获技术进行13种高危型人乳头瘤病毒检测。对HPV阳性和细胞学为ASCUS及以上患者均进行阴道镜下活组织病理检查。结果:当HC2与TCT联合检测时,对于CIN2及以上病变诊断的敏感度、特异度、阳性预测值和阴性预测值分别为97.4%、81.6%、90.6%和94.5%,均较单独应用时显著提高;在慢性宫颈炎、CIN1、CIN2、CIN3和宫颈癌中HR-HPV的阳性率分别为37.7%、76.1%、85.9%和91.8%和91.7%,随着宫颈病变严重程度的增加,HR-HPV感染率明显增加。结论:HC2-HPV与TCT联合检测在宫颈癌的筛查中可提高诊断的准确性。Objective：To explore the clinical values of second-generation hybrid capture technology and liquid-based thinprep cytology in screening of cervical cancer.Methods：Liquid-based thinprep cytology was used for cytological examination,and second-generation hybrid capture technology was adopted for 13 kinds of high risk human papillomavirus detection;all the patients with positive HPV and cytological results≥ASCUS underwent biopsy and pathological examination under colposcope.Results：The sensitivity,specificity,positive predictive value and negative predictive value of joint detection of HC2 and TCT for cases with TCT results≥CIN2 were 97.4%,81.6%,90.6% and 94.5%,respectively,which were significantly higher than those of single detection;the positive rates of HR-HPV in chronic cervicitis,CIN1,CIN2,CIN3 and cervical carcinoma were 37.7%,76.1%,85.9%,91.8% and 91.7%,respectively;the infective rate of HR-HPV increased significantly with the increase of severity degrees of cervical lesions.Conclusion：Joint detection of HC2-HPV and TCT may improve the diagnostic accuracy in screening of cervical cancer.

关 键 词：人乳头瘤病毒 二代杂交捕获 宫颈癌 液基细胞学 

分 类 号：R737.3[医药卫生—肿瘤]