MMP-26蛋白在子宫颈癌中的表达及意义  

Expression of MMP-26 protein in cervical carcinoma and its significance

作　　者：徐琳[1] 李会敏[2] 刘志晶[2] 董欣洁[2] 张玉辉[2] 李伟[2] 李一雷[2] 

机构地区：[1]吉林省人民医院妇产科,吉林长春130021 [2]吉林大学病理生物学教育部重点实验室

出　　处：《中国妇幼保健》2010年第30期4435-4438,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金资助项目〔30470662;36870970〕;吉林省卫生厅项目〔20082079〕;吉林省科技厅项目〔200905179〕

摘　　要：目的:检测基质金属蛋白酶-26(Matrix metalloproteinase-26,MMP-26)在子宫颈癌中的表达,分析其与临床病理特征的关系,阐明其在子宫颈癌发生和发展中的作用和意义。方法:应用免疫组织化学染色方法检测MMP-26蛋白在10例正常子宫颈及107例宫颈原位癌和浸润癌中的表达,分析其与子宫颈癌临床病理特征的关系。结果:MMP-26在宫颈原位癌和浸润癌中均呈强阳性表达,阳性率分别为83.33%和82.47%,阳性表达部位主要集中于肿瘤细胞的胞浆中,同时可见癌巢的边缘和基底细胞样癌细胞呈现MMP-26强阳性。MMP-26在宫颈原位癌和浸润癌中的表达阳性率与正常宫颈相比具有统计学差异(P<0.05)。MMP-26的表达与子宫颈癌的肌层浸润深度和淋巴结转移密切相关(P<0.05),而与组织学类型、临床分期、病理分级及患者的年龄无关。结论:MMP-26在子宫颈癌的早期侵袭和转移过程中发挥重要作用,可能成为宫颈癌早期诊断和转移的标志性因子。Objective：To detect the expression of matrix metalloproteinase-26（MMP-26） in cervical carcinoma,analyze its relationship with clinical pathological characteristics,demonstrate its effect and significance in occurrence and development of cervical carcinoma.Methods：The expression levels of MMP-26 protein in 10 cases with normal cervical tissues,107 cases with cervical carcinoma in situ and invasive cervical carcinoma were detected by immunohistochemical staining,its relationship with clinical pathological characteristics of cervical carcinoma was analyzed.Results：MMP-26 showed strong positive staining in cervical carcinoma in situ and invasive cervical carcinoma,their positive rates were 83.33% and 82.47%,respectively.The positive staining mostly located in the cytoplasm of tumor cells,margins of cancer nests and basal cell carcinoma cells;there was significant difference in MMP-26 expression level between cervical carcinoma in situ,invasive cervical carcinoma and normal cervical tissues（P0.05）.There was correlation between MMP-26 expression and myometrium invasion depth of cervical carcinoma,lymph node metastasis,but MMP-26 was not correlated with histological types,clinical stages,pathological grades and ages.Conclusion：MMP-26 plays an important role in early invasion and metastasis of cervical carcinoma,which may be a potential marker of early diagnosis and metastasis of cervical carcinoma.

关 键 词：子宫颈癌 基质金属蛋白酶-26 侵袭 转移 

分 类 号：R737.3[医药卫生—肿瘤]