乳腺癌中EBP50、E-cadherin和β-catenin的表达及意义  

The expression of EBP50,β-catenin and E-cadherin in human breast cancer tissue and its significance

作　　者：时志民[1] 柳继兴[1] 刘惠民[1] 王蕾[1] 杨习星[2] 

机构地区：[1]河北工程大学医学院病理学教研室,河北邯郸056029 [2]河北邯郸矿业集团有限公司总医院

出　　处：《中国实验诊断学》2010年第10期1558-1560,共3页Chinese Journal of Laboratory Diagnosis

基　　金：邯郸市科学技术局资助项目(0920108055-4)

摘　　要：目的研究乳腺癌组织中EBP50、E-cadherin及β-catenin蛋白的表达与临床病理指标的关系及其预后意义。方法应用免疫组化SP法,检测56例乳腺癌、30例癌旁正常乳腺组织石蜡切片中EBP50、E-cadherin、β-catenin的表达与临床病理学指标之间的关系。结果①56例乳腺癌组织中EBP50、E-cadherin和β-catenin的表达率分别为37.50%、41.07%和39.28%,与正常乳腺组织相比有显著性差异(P<0.05)。②EBP50、E-cadherin以及β-catenin的表达与乳腺癌的组织学分级、临床TNM分期和淋巴结转移有关(P<0.05),而与患者年龄大小、原发肿瘤大小无关(P<0.05)。③在乳腺癌中EBP50与E-cadherin表达水平呈显著正相关(P<0.05),且与核表达β-catenin呈显著负相关(P<0.05)。结论 EBP50、E-cadherin和β-catenin的异常表达与乳腺癌的发生、发展及浸润转移有关,可作为判断乳腺癌生物学行为和预后的重要指标。Objective To investigate the expression of EBP50,E-cadherin andβ-catenin in human breast cancer tissue,study their relationship with clinicopathological factor in breast cancer,and analyze their expression significance and their correlation with each other.Methods The expression of EBP50,E-cadherin andβ-catenin in 56cases of breast carcinoma and 30 cases of adjacent nontumor normal breast tissue was detected by SP immunohistochemistry.Results ①The postitive expression of EBP50,E-cadherin andβ-catenin in 56 cases of breast carcinoma were37.50%,41.07% and 39.28% respectively.There was a significant different between carcinoma and normal breast tissue（P 0.05）;②The expression of EBP50,E-cadherin andβ-catenin in breast carcinoma had no relationship with age and the size of primary tumor,but had some relationship with histological classification,clinical TNM staging,and lymph node metastasis（P0.05）;③EBP50 in breast cancer with the E-cadherin expression level was significantly positively correlated（P0.05）,and the nuclear expression of β-catenin was significantly negatively correlated（P0.05）.Conclusion The abnormal expression of EBP50,E-cadherin and β -catenin relate to occurrence,development and invasion and metastasis.They may be as the indications of biological behavior and prognosis of breast carcinoma.

关 键 词：乳腺肿瘤 EBP50 E-CADHERIN Β-CATENIN 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]