急性进展性脑梗死患者外周血单个核细胞趋化因子受体1及锌指蛋白A20表达的研究  

Study of expression of CX3CR1 and zinc finger protein in peripheral blood mononuclear cells of patients with acute progressive cerebral infarction

作　　者：毛德军[1] 宫相聪 李秀珍[1] 郭瑞友[1] 臧云华[1] 

机构地区：[1]青岛大学医学院附属海慈医疗集团神经内科,青岛266033 [2]青岛市即墨兰村中心卫生院内科,青岛266232

出　　处：《中国免疫学杂志》2010年第10期937-939,共3页Chinese Journal of Immunology

基　　金：青岛市2007年医药科研指导计划(No.2007WSZD071)

摘　　要：目的:研究急性进展性脑梗死(Acute progressive cerebral infarction,APCI)患者外周血单个核细胞(Peripheral blood mononuclear cells,PBMC)趋化因子受体1(CX3C-chemokine receptor 1,CX3CR1)及锌指蛋白A20表达的变化。方法:采用前瞻性研究,选择起病7天内的99例APCI患者作为APCI组,选择同期未进展的急性脑梗死(Acute cerebral infarction,ACI)患者及门诊查体的脑动脉硬化(Cerebral arteriosclerosis,CAS)患者各100例分别作为ACI组和CAS组;CAS组于查体时,APCI组及ACI组于入院时、病程第7、14、30天分别监测PBMCCX3CR1及锌指蛋白A20表达的变化。结果:APCI组于入院时、病程第7天、第14天及第30天PBMCCX3CR1表达均明显高于ACI组(P均<0.05)。结论:APCI患者PBMCCX3CR1表达的过度上调,可能是APCI发生与发展的分子生物学机制之一。Objective： To study the expressional changes of CX3C-chemokine receptor 1 （CX3CR1） and zinc finger protein A20 in peripheral blood mononuclear cells （PBMC） of patients with acute progressive cerebral infarction（APCI）. Methods：We selected ninety-nine patients getting APCI less than 7 d of the onset as APCI group by prospective method. 100 cases of patients with non-progressive acute cerebral infaction（ACI） in the same and with screening cerebral arteriosclerosis（CAS） in the outpatient were respectively selected as ACI group and CAS group. The expressional changes of CX3CR1 and zinc finger protein A20 in PBMC of patients with CAS on admission, of patients with APCI and ACI in hospital, on the course of seventh day, of fourteen and of thirtieth were detected respectively. Results： The expression of CX3CR1 in PBMC of patients in APCI group was higher in ACI group in hospital, on the course of seventh day, of fourteen and of thirtieth （ all P 〈 0.05）. Conclusion： The excessive increase of expression of CX3CR1 in PBMC might be one of the molecular biology mechanisms of onset and progress for APCI.

关 键 词：脑梗死 趋化因子受体1 锌指蛋白A20 

分 类 号：R743.32[医药卫生—神经病学与精神病学]