纹状体参与数字记忆广度的fMRI评价  

Striatum involved in digital memory span:Evaluation with fMRI

作　　者：郑金龙[1,2] 舒斯云[1] 刘颂豪[1] 张增强[1] 韩立新[3] 

机构地区：[1]华南师范大学认知神经科学研究所,广东广州510631 [2]徐州医学院附属淮安医院神经内科,江苏淮安223002 [3]广州军区广州总医院磁共振室,广东广州510010

出　　处：《中国医学影像技术》2010年第10期1830-1832,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(30270431)

摘　　要：目的运用功能磁共振成像(fMRI)技术检测健康人脑纹状体是否参与数字记忆广度的认知过程。方法在18名右利手健康人接受数字记忆广度任务时行fMRI扫描。试验采用组块设计并选用SPM99软件行数据分析和脑功能区定位,记录各激活脑区的像素值并计算偏侧化指数值。结果采用单样本t检验,阈值设为P<0.0001时,主要激活的大脑皮质脑区为左颞叶视区(T=11.19),主要激活的皮质下结构为纹状体(T左=8.01、T右=8.53)。激活脑区像素值的偏侧化指数值为0.09。结论数字记忆广度的认知过程是由大脑皮质和纹状体等皮质下结构共同协作完成的。Objective To examine whether the striatum was involved in digital memory span cognitive function of human brain with functional magnetic resonance imaging （fMRI） technique. Methods Eighteen right-handed healthy volunteers participated in the test of digital memory span while the fMRI data were recorded. Control tasks were performed for the block-design. SPM 99 was used to analyze the data and to obtain the activated brain regions. Numbers of activated voxels were used to calculate lateralization index. Results When the threshold was set as P0.0001,using one-sample t-test,the most striking activation region of cerebral cortex was the left inferior temporal gyrus （T=11.19）,while the remarkably activated subcortial structure was striatum （Tleft=8.01,Tright=8.53） during the memory task. Lateralization index of the numbers of activated voxels was 0.09. Conclusion The subcortical structures as well as the cerebral cortex are collaborative to contribute to digital memory span cognitive function in human brain.

关 键 词：数字记忆 记忆广度 磁共振成像 纹状体 

分 类 号：R338.2[医药卫生—人体生理学] R445.2[医药卫生—基础医学]