超声引导下经皮注射无水乙醇量化治疗老年原发性肝癌的临床价值  

Clinical value of ultrasound guided percutaneous quantified ethanol injection in the treatment of primary hepatic carcinoma in the elders

作　　者：魏洪芬[1] 林礼务[1] 薛恩生[1] 林学英[1] 俞丽云[1] 

机构地区：[1]福建医科大学附属协和医院超声科,福建福州350001

出　　处：《中国医学影像技术》2010年第10期1908-1911,共4页Chinese Journal of Medical Imaging Technology

基　　金：福建省科委研究基金资助课题(2000Z138)

摘　　要：目的评价超声引导下经皮注射无水乙醇量化(PQEI)治疗老年原发性肝癌的临床价值。方法临床诊断或病理证实的老年原发性肝癌患者94例,均接受超声引导下PQEI治疗。所有病例随访12～60个月,观察临床症状与体征,并结合相关检查结果,统计1～5年生存率。结果 94例老年原发性肝癌患者经PQEI治疗后1、2、3、4、5年生存率分别为94.05%,83.08%,72.00%,56.25%和46.42%,中位生存期为46.1个月,直径≤3cm肝癌患者1、3、5年生存率明显高于直径>3cm的肝癌患者(P均<0.01),治疗后肿瘤平均直径从3.6cm降为2.7cm。结论超声引导下PQEI治疗老年原发性肝癌有较高的临床价值。Objective To explore the clinical value of ultrasound guided percutaneous quantified ethanol injection （PQEI） in the treatment of primary hepatic carcinoma （PHC） in the elderds. Methods Ninty-four elderpatients with PHC proved by clinic or pathology were treated with ultrasound guided PQEI every 2—3 days. The follow-up period lasted 12—60 months. The therapeutic efficacy was assessed according to clinical symptom,the result of AFP,ultrasonography,CT,MRI and biopsy. The survival rate of 1,2,3,4,5 years was calculated. Results The survival rate of 1,2,3,4,5 years was 94.05%,83.08%,72.00%,56.25% and 46.42%,respectively. The median survival time was 46.1 months.The survival rates of 1,3,5 years of patients with hepatic carcinomas ≤3 cm in diameter were markedly higher than those of patients of hepatic carcinomas 3 cm in diameter （all P0.01）. Average diameter shrank from 3.6 cm to 2.7 cm after 2—8 weeks since the last PQEI. Conclusion The treatment efficacy of PQEI for PHC in the elders is of high clinical value and deserves further research.

关 键 词：肝肿瘤 老年人 超声检查 介入性 无水乙醇量化治疗 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]