鼻咽癌放疗前后腭帆张肌横截面积的改变与分泌性中耳炎的相关性分析  

Analysis on the relationship between tensor veli palatini and secretory otitis media inpatients with nasopharyngeal carcinoma after radiotherapy

作　　者：高艺玲[1] 唐安洲[1] 刘津[1] 王晓明[1] 何光耀[1] 闵志刚[2] 

机构地区：[1]广西医科大学第一附属医院耳鼻咽喉头颈外科,南宁530021 [2]广西医科大学第一附属医院放射科

出　　处：《临床耳鼻咽喉头颈外科杂志》2010年第16期743-745,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:分析腭帆张肌(TVP)放射性损伤与放疗后分泌性中耳炎(SOM)的关系,探讨鼻咽癌放疗后SOM的发病机制。方法:选取经病理确诊为鼻咽癌并接受放疗的32例患者,测量放疗前后磁共振上TVP和翼内肌(MP)的横截面积,同时观察放疗后SOM的发生情况,统计并分析放疗后TVP改变与SOM发生的关系。结果:在放疗前无SOM的48耳中,放疗后并发SOM的有27耳,其中伴有TVP萎缩者24耳,无萎缩者3耳;放疗后无SOM的有21耳,其中伴有TVP萎缩者8耳,无萎缩者13耳。经χ2检验差异有统计学意义(P<0.01),即放疗后SOM的发生与TVP的萎缩存在相关性。放疗后的时间越长TVP就越有萎缩的可能。结论:鼻咽癌放疗后患者的TVP在6个月以后有明显萎缩倾向,而且放疗后SOM的发生可能与TVP放射性损伤有关;放疗后SOM的发生机制有待从功能上作进一步研究。Objective：Tto analyze the relationship between secretory otitis media（SOM）and injury of tensor veli palatini （TVP）muscle injury after radiotherapy,then to explore the pathogenesis of SOM in patients with nasopharyngeal carcinoma （NPC）after radiotherapy.Method：The cross section area （CSA）of TVP and medial pterygoid（MP）muscle were measured in MRI of 32patients with NPC before and after radiotherpy,meanwhile the incidence of SOM were surveyed after radiotherapy,then to analyze the relationship between the change of TVP and the incidence of SOM after radiotherapy.Result：Of 48ears without SOM before radiotherpy,27ears developed post-irradiation SOM,including 24ears with TVP atrophy and 3ears without TVP atrophy ,and 21ears had no post-irradiation SOM,including 8ears with TVP atrophy and 13ears without TVP atrophy.χ2test showed significant difference （P0.01）.It indicated that post-irradiation SOM have correlation with TVP atrophy.The more possibility of TVP atrophy occurred after long time ratiotherpy.Conclusion：The atropy of TVP in patients with NPC usually occurs 6months after radiotherapy,and this may result in the post-irradiation SOM.The pathogenesis of post-irradiation SOM need further study functionally.

关 键 词：鼻咽肿瘤 放射治疗 中耳炎 伴渗出液 腭帆张肌 

分 类 号：R739.63[医药卫生—肿瘤]