对Ⅰb2至Ⅱb期宫颈癌术前新辅助化疗临床疗效观察  

Effect of neoadjuvent chemotherapy of cervical cancer of stage Ⅰb2-Ⅱb

作　　者：宋淑芳[1] 张林燕[1] 宋静慧[1] 

机构地区：[1]内蒙古医学院第一附属医院妇产科,呼和浩特010059

出　　处：《中国医药》2010年第11期1044-1046,共3页China Medicine

摘　　要：目的 探讨新辅助化疗在局部晚期宫颈癌治疗中的临床应用价值. 方法 收集2005年12月至2008年12月在我院妇科住院行BIP方案新辅助化疗的48例Ⅰb2～Ⅱb期宫颈癌患者的临床资料进行回顾 性分析. 结果 48例给予BIP方案静脉化疗1一2个疗程,化疗后42例顺利完成宫颈癌根治术,6例化疗无效改行全量放疗.48例患者共化疗61个疗程,临床总有效率87.5%（42/48）,其中完全缓解9例,部分缓解33例,稳定6例.鳞癌有效率高于腺癌（P＜0.05）,临床分期及组织学分级对化疗效果无影响（P＞0.05）.42例接受新辅助化疗后顺利完成宫颈癌根治术,手术率87.5%. 结论 局部晚期宫颈癌术前新辅助化疗近期疗效显著,降低临床分期,提高手术切除率,改善了宫颈癌患者治疗后生活质量.Objective To explore the clinical value of neoadjuvant chemotherapy（NACT）for locally advanced cervical carcinoma. Methods A total of 48 patients with cervical carcinoma at stage Ⅰb2 to Ⅱb during 2005.12 to 2008.12 were treated with intravenous chemotherapy by regimen of BIP chemotherapy for 1 to 2 courses followed by 42 cases with radical hysterectomy and pelvic lymphadenectomy and 6 cases at Ⅱb stage with radiotherapy. Results The overall efficacy rate was 87.5%,13 of 48 cases were relieved completely,including complete pathological response in five patients.Twenty-mine cases were relieved partially.Six cases were stable diseases.The efficacy rate of squamous carcinoma was higher than the adenocarcinoma.The clinical stage and histology class were unrelated to the efficacy.Forty two patients underwent surgery after NACT.NACT showed short term effect on locally advanced cervical cancer. Conclusion NACT shows short term effect on locally advanced cervical cancer,increases the resection rate and improves the patients＇ living quality after treatment.

关 键 词：宫颈肿瘤 新辅助化疗 妇科外科手术 

分 类 号：R737.33[医药卫生—肿瘤]